uORFs, reinitiation and alternative translation start sites in human mRNAs

Кочетов, А. В.; Ahmad, Shandar; Иванисенко, В. А.; Volkova, Oxana A.; Колчанов, Н. А.; Sarai, Akinori

doi:10.1016/j.febslet.2008.03.014

Cited by 59 publications

(66 citation statements)

References 36 publications

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“…There is an in-frame upstream stop codon (TAG) in the 5 0 -UTR before the main ORF of the rainbow trout ACKR2 gene, suggesting the complete ORF had been correctly predicted in this species. A short ORF encoding for 10 aa is also present in the 5 0 -UTR that may be involved in the regulation of the trout ACKR2 translation [45] (Fig. S1).…”

Section: Cloning and Characterisation Of Ackr2 In Rainbow Trout And Smentioning

confidence: 99%

Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)

Qi¹,

Jiang

Holland

et al. 2015

Fish & Shellfish Immunology

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Section: Cloning and Characterisation Of Ackr2 In Rainbow Trout And Smentioning

confidence: 99%

Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)

Qi¹,

Jiang

Holland

et al. 2015

Fish & Shellfish Immunology

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“…(41,(67)(68)(69) Functional roles of many uORFs and uORFencoded peptides were predicted with the aid of various computational approaches. (78)(79)(80)(81)(82) It was found that some orthologous eukaryotic genes are characterized by conservative uAUG triplets, which suggests their importance in expression control. (78) Similarly, ca.…”

Section: Types Of Alternative Open Reading Framesmentioning

confidence: 99%

Alternative translation start sites and hidden coding potential of eukaryotic mRNAs

2008

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SummaryIt is widely suggested that a eukaryotic mRNA typically contains one translation start site and encodes a single functional protein product. However, according to current points of view on translation initiation mechanisms, eukaryotic ribosomes can recognize several alternative translation start sites and the number of experimentally verified examples of alternative translation is growing rapidly. Also, the frequent occurrence of alternative translation events and their functional significance are supported by the results of computational evaluations. The functional role of alternative translation and its contribution to eukaryotic proteome complexity are discussed.

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“…What happened to the simple, whole formalin killed or UV killed less pathogenic EBOV vaccines that have been tried in so many viral vaccinations? [60] With viruses like the major Ebola strands, where the mortality rate is over 50%, it will be difficult to find a reasonable and ethical way to carry out an unbiased clinical trial. However, if one can prepare a "dead Ebola virus" with antigenicity intact, it would be easy to immunize "high risk groups" without utilizing unusual vectors as exemplified by "harmless" Chimpanzee adenovirus, VSV or MVA (modified smallpox virus), each with unknown long-term risk factors and accompanied by immediate concerns of viral vectorinduced antigenic competition that may potentially quell proper immune responses to the Ebola antigens [61][62][63].…”

Section: Nomentioning

confidence: 99%

Inhibition of Ebola Virus by Anti-Ebola miRNAs in silico

Golkar

Battaria

Pace

et al. 2016

J Infect Dev Ctries

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Introduction: MicroRNAs (miRNAs) are small, noncoding RNA molecules that regulate transcriptional and posttranscriptional gene regulation of the organisms. miRNA provides immune defense when the body is faced with challenges intracellular agents. miRNA molecules trigger gene silencing in eukaryotic cells. More than 3,000 different human miRNAs (hsa-miRs) have been identified thus far. During ontogenesis, viral or intracellular parasitic infections, miRNAs are differentially expressed to protect the host from intracellular invaders. In a viral infection context, miRNAs have been connected with the interplay between host and pathogen, and occupy a major role in pathogenesis. Methodology: An in silico approach was used to analyze the four major Ebola Virus genome sequences including the recently characterized Ebola virus responsible for West African epidemic that has killed over 10,000 people. All totaled, 2,543 mature human miRNA sequences were retrieved through an miR-database, and the identification of mature miRNAs were aligned with full length sequences of the four major Ebola viruses via computational tools. Results: We identified 32 miRNAs that exhibited significant inhibitory capacity to block more than one EBV strains. miR-607 showed capacity to quell all four major EBVs. Ten putative miRNAs were found to have near perfect identity at seed sequences with numerous targets of Ebola virus that may completely degrade the viral transcripts. Conclusion: We hypothesize that a miRNA-based vaccine can quell Ebola virus infection. Future approaches will focus on validation of these miRNAs in quelling the Ebola virus to further elucidate their biological functions in primate and other animal models.

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uORFs, reinitiation and alternative translation start sites in human mRNAs

Cited by 59 publications

References 36 publications

Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)

Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)

Alternative translation start sites and hidden coding potential of eukaryotic mRNAs

Inhibition of Ebola Virus by Anti-Ebola miRNAs in silico

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