Unveiling Tryptophan Dynamics and Functions Across Model Organisms via Quantitative Imaging
Kui Wang,
Tian-lun Chen,
Xin-xin Zhang
et al.
Abstract:Tryptophan is an essential amino acid involved in many cellular processes in vertebrates. Systemic and quantitative measurement of tryptophan is crucial for evaluating its essential role as a precursor of serotonin and kynurenine, key neuromodulators affecting neural and immune functions. We utilized a robust and highly responsive ratiometric indicator for tryptophan (GRIT) to quantitatively measure tryptophan dynamics in bacteria, mitochondria of mammalian cell cultures, and human serum. At the cellular scale… Show more
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