Unveiling the stochastic nature of human heteropolymer ferritin self‐assembly mechanism
Fadi Bou‐Abdallah,
Jeremie Fish,
Genki Terashi
et al.
Abstract:Despite ferritin's critical role in regulating cellular and systemic iron levels, our understanding of the structure and assembly mechanism of isoferritins, discovered over eight decades ago, remains limited. Unveiling how the composition and molecular architecture of hetero‐oligomeric ferritins confer distinct functionality to isoferritins is essential to understanding how the structural intricacies of H and L subunits influence their interactions with cellular machinery. In this study, ferritin heteropolymer… Show more
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