Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications

Cotin, Geoffrey; Blanco-Andujar, Cristina; Perton, Francis; Asín, Laura; Fuente, Jesús M. de la; Reichardt, Wilfried; Schaffner, Denise; Ngyen, Dinh-Vu; Mertz, Damien; Kiefer, Céline; Meyer, Florent; Spassov, Simo; Ersen, Ovidiu; Chatzidakis, Michael; Botton, Gianluigi A.; Henoumont, Céline; Laurent, Sophie; Grenèche, Jean‐Marc; Terán, Francisco J.; Ortega, Daniel; Felder‐Flesch, Delphine; Bégin‐Colin, Sylvie

doi:10.1039/d1nr03335b

Cited by 25 publications

(21 citation statements)

References 82 publications

(127 reference statements)

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Section: Synthesis Proceduresmentioning

confidence: 99%

“…The colloidal stability was characterized in different physiological media by DLS measurements, and at least the conditions of biologically relevant solutions were given to some extent in the supplementary materials in an article published recently. 173 In colloid science, the coagulation kinetics measurement and analysis of kinetic data to determine the critical coagulation concentration (ccc), i.e. the lowest concentration of electrolyte that induces fast coagulation is a widely accepted method to characterize colloid stability; the ccc value and the stability plot are comparable to DLVO theory.…”

Section: On the Colloidal Stability Of Ferrofluids And Bioferrofluidsmentioning

confidence: 99%

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Ferrofluids and bio-ferrofluids: looking back and stepping forward

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Section: Synthesis Proceduresmentioning

confidence: 99%

Section: On the Colloidal Stability Of Ferrofluids And Bioferrofluidsmentioning

confidence: 99%

Ferrofluids and bio-ferrofluids: looking back and stepping forward

et al. 2022

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“…In recent years, nanoparticles have been shown to possess stronger biocompatibility and more efficient tumour targeting capability through reasonable functionalization and modification. By adjusting their surface properties and the size and shape of nanoparticles, their drug toxicity and pharmacokinetics can be changed both in vitro and in vivo ( 164 ). In this article, we reviewed the biomedical applications of different nanoparticles, including metal/metallic compounds, non-metallic nanoparticles, polymeric nanoparticles, and liposomes, in various digestive tumours ( Table 1 ).…”

Section: Future Perspectives and Summarymentioning

confidence: 99%

Opportunities and Challenges of Nanoparticles in Digestive Tumours as Anti-Angiogenic Therapies

et al. 2022

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Digestive tumours, a common kind of malignancy worldwide, have recently led to the most tumour-related deaths. Angiogenesis, the process of forming novel blood vessels from pre-existing vessels, is involved in various physiological and pathological processes in the body. Many studies suggest that abnormal angiogenesis plays an important role in the growth, progression, and metastasis of digestive tumours. Therefore, anti-angiogenic therapy is considered a promising target for improving therapeutic efficacy. Traditional strategies such as bevacizumab and regorafenib can target and block the activity of proangiogenic factors to treat digestive tumours. However, due to resistance and some limitations, such as poor pharmacokinetics, their efficacy is not always satisfactory. In recent years, nanotechnology-based anti-angiogenic therapies have emerged as a new way to treat digestive tumours. Compared with commonly used drugs, nanoparticles show great potential in tumour targeted delivery, controlled drug release, prolonged cycle time, and increased drug bioavailability. Therefore, anti-angiogenic nanoparticles may be an effective complementary therapy to treat digestive tumours. In this review, we outline the different mechanisms of angiogenesis, the effects of nanoparticles on angiogenesis, and their biomedical applications in various kinds of digestive tumours. In addition, the opportunities and challenges are briefly discussed.

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“…When arranged in more complex structures, nanoparticles gain superior properties such as improved bioavailability, targeting capabilities, and theragnostic properties [37]. Spherical and octopod particles, apart from their imaging properties, also possess the ability to produce heat [38]. Size also influences their properties.…”

Section: Medical Uses Of Iron Copper and Zinc Nanoparticlesmentioning

confidence: 99%

“…This is the basis for localized hyperthermia. This method allows for precise targeting of neoplastic tissues while preventing any damage from occurring to healthy cells [37,38].…”

Section: Theranosticsmentioning

confidence: 99%

Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications

2021

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Understanding of how the human organism functions has preoccupied researchers in medicine for a very long time. While most of the mechanisms are well understood and detailed thoroughly, medicine has yet much to discover. Iron (Fe), Copper (Cu), and Zinc (Zn) are elements on which organisms, ranging from simple bacteria all the way to complex ones such as mammals, rely on these divalent ions. Compounded by the continuously evolving biotechnologies, these ions are still relevant today. This review article aims at recapping the mechanisms involved in Fe, Cu, and Zn homeostasis. By applying the knowledge and expanding on future research areas, this article aims to shine new light of existing illness. Thanks to the expanding field of nanotechnology, genetic disorders such as hemochromatosis and thalassemia can be managed today. Nanoparticles (NPs) improve delivery of ions and confer targeting capabilities, with the potential for use in treatment and diagnosis. Iron deficiency, cancer, and sepsis are persisting major issues. While targeted delivery using Fe NPs can be used as food fortifiers, chemotherapeutic agents against cancer cells and microbes have been developed using both Fe and Cu NPs. A fast and accurate means of diagnosis is a major impacting factor on outcome of patients, especially when critically ill. Good quality imaging and bed side diagnostic tools are possible using NPs, which may positively impact outcome.

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Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications

Abstract: Iron oxide nanoparticles (IONPs) are well-known contrast agents for MRI for a wide range of sizes and shapes. Their use as theranostic agents requires a better understanding of their magnetic...

Cited by 25 publications

References 82 publications

Ferrofluids and bio-ferrofluids: looking back and stepping forward

Ferrofluids and bio-ferrofluids: looking back and stepping forward

Opportunities and Challenges of Nanoparticles in Digestive Tumours as Anti-Angiogenic Therapies

Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications

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