Unveiling the Links Between Microbial Alteration and Host Gene Disarray in Crohn's Disease via TAHMC
Huijun Chang,
Yongshuai Liu,
Yue Wang
et al.
Abstract:A compelling correlation method linking microbial communities and host gene expression in tissues is currently absent. A novel pipeline is proposed, dubbed Transcriptome Analysis of Host‐Microbiome Crosstalk (TAHMC), designed to concurrently restore both host gene expression and microbial quantification from bulk RNA‐seq data. Employing this approach, it discerned associations between the tissue microbiome and host immunity in the context of Crohn's disease (CD). Further, machine learning is utilized to separa… Show more
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