Unveiling the inhibitory mechanism of aureusidin targeting xanthine oxidase by multi-spectroscopic methods and molecular simulations

He, Pei; Xu, Haiqi; Yang, Can; Yu, Dehong; Liu, Yi; Du, Jiana; Li, Yanfang

doi:10.1039/d2ra06997k

Cited by 4 publications

(2 citation statements)

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“…In addition, AUR showed good stability and pharmacokinetic behavior properties in molecular dynamics simulation and ADMET prediction. Overall, our work unveiled the AUR binding mechanism AUR to XO and also provided valuable information concerning the future therapeutic application of AUR as a natural XO inhibitor (He et al, 2023).…”

Section: Antihyperuricemia Activitymentioning

confidence: 72%

“…AUR acted as a rapid reversible and mixed‐type XO inhibitor (IC 50 = 7.617 ± 0.401 μM); its binding to XO was spontaneous and dominated mainly by hydrophobic interaction. AUR quenched the fluorescence chromophore of XO by forming XO–AUR complex in a static quenching mechanism (He et al., 2023). In particular, it could occupy the catalytic center (Mo‐Pt domain), prevent the entrance of substrate, and induce the conformational changes of secondary structures of XO, which further affected the XO protein tertiary structure.…”

Section: In Vitro Bioactivity Of Aurmentioning

confidence: 99%

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A multifaceted review on aureusidin in planta distribution, (bio)synthesis, and bioactivities

Huang,

Lin,

Farag

et al. 2023

Food Safety and Health

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Aureusidin, a derivative of aurone, imparts a vibrant yellow hue to numerous yellow‐rich plants, such as sunflowers and snapdragons. The bright yellow color provides an excellent pigment of choice for plant breeders to cultivate different‐colored hybrid species. The biosynthesis of aureusidin relies on a key aureusidin synthase enzyme, which belongs to the plant polyphenol oxidase family. The revelation of its DNA sequence, coupled with transgenic technology, has opened up possibilities for producing exceptionally stunning flower plants. Moreover, aureusidin exhibits remarkable bioactivities in vitro, including anti‐microbial, anti‐viral, anti‐cancer, anti‐inflammatory, anti‐oxidant, anti‐diabetic, anti‐hypercholesterolemic, anti‐hyperuricemia, histone deacetylase inhibitory, and neuropharmacological properties. However, the majority of studies have focused on in vitro experiments, rather than in vivo disease models, toxicological assessments, and human clinical trials. This review provides a comprehensive overview of all research advancements pertaining to aureusidin highlighting future perspectives to maximize its value, hereby contributing to the application of medicine, agricultural, and biotechnology fields. More studies are needed in the future to assess its toxicology, safety, and biotransformation for potential incorporation in future nutraceuticals.

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Section: Antihyperuricemia Activitymentioning

confidence: 72%

Section: In Vitro Bioactivity Of Aurmentioning

confidence: 99%