Unveiling the Impact of Hemodynamics on Endothelial Inflammation‐Mediated Hepatocellular Carcinoma Metastasis Using a Biomimetic Vascular Flow Model
Jia He,
Peiyan Duan,
Yi Liu
et al.
Abstract:Distant metastasis of hepatocellular carcinoma (HCC) mediated by hematogenous dissemination is a leading cause of HCC‐related deaths. The inflammatory response of vascular endothelial cells facilitates this process by promoting the adhesion and invasion of tumor cells in the circulatory system. While the regulation of this inflammation‐mediated metastasis through upregulation of adhesion molecules and disruption of intercellular junctions has been well established, the contribution of hemodynamics to this proc… Show more
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