Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review

Perrottelli, Andrea; Giordano, Giulia; Brando, Francesco; Giuliani, Luigi; Pezzella, Pasquale; Mucci, Armida; Galderisi, Silvana

doi:10.3390/diagnostics12092193

Cited by 15 publications

(13 citation statements)

References 295 publications

(530 reference statements)

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“…Our results are also consistent with these studies. In addition, schizophrenic patients with attention deficits are prone to symptoms such as fantasies and cognitive disorders, which may be related to their lower gamma oscillations ( 47 , 48 ). Increased prefrontal gamma oscillations may be associated with the fact that musical rhythms and melodies increase patients’ interest and enhance auditory attention ( 49 ).…”

Section: Discussionmentioning

confidence: 99%

Five-week music therapy improves overall symptoms in schizophrenia by modulating theta and gamma oscillations

Wang,

Chen

et al. 2024

Front. Psychiatry

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IntroductionSome clinical studies have shown that music therapy as an adjunctive therapy can improve overall symptoms in patients with schizophrenia. However, the neural mechanisms of this improvement remain unclear due to insufficient neuroimaging evidence.MethodsIn this work, 17 patients with schizophrenia accepted a five-week music therapy (music group) that integrated listening, singing, and composing, and required patients to cooperate in a group to complete music therapy tasks. Meanwhile, 15 patients with schizophrenia received a five-week visual art intervention as the control group including handicraft and painting activities. We collected the Manchester Scale (MS) and Positive and Negative Symptom Scale (PANSS) scores and electroencephalography (EEG) data before and after intervention in two groups.ResultsBehavioral results showed that both interventions mentioned above can effectively help patients with schizophrenia relieve their overall symptoms, while a trend-level effect was observed in favor of music therapy. The EEG results indicated that music therapy can improve abnormal neural oscillations in schizophrenia which is reflected by a decrease in theta oscillation in the parietal lobe and an increase in gamma oscillation in the prefrontal lobe. In addition, correlation analysis showed that in the music group, both reductions in theta oscillations in the parietal lobe and increases in gamma oscillations in the prefrontal lobe were positively correlated with the improvement of overall symptoms.DiscussionThese findings help us to better understand the neural mechanisms by which music therapy improves overall symptoms in schizophrenia and provide more evidence for the application of music therapy in other psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Five-week music therapy improves overall symptoms in schizophrenia by modulating theta and gamma oscillations

Wang,

Chen

et al. 2024

Front. Psychiatry

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“…EEG beta rhythm oscillations play an important role in top-down signaling and feedback influences for cortical neurons that effectively support the precise synchronization of neuronal discharges [11,50]. Patients with schizophrenia were reported to have disturbances in both top-down signaling and EEG beta-band coordination [50].…”

Section: Discussionmentioning

confidence: 99%

“…There is convergent evidence that aberrant neural oscillations at low-and highfrequencies constitute an important aspect of the failure to generate coherent cognition, causing the characteristic cognitive deficits of schizophrenia [10,11]. These deficits are attributed to N-methyl-D-aspartate receptor hypofunction and could be assessed in schizophrenia patients with electroencephalography (EEG) [12].…”

Section: Introductionmentioning

confidence: 99%

Resting-State EEG Connectivity at High-Frequency Bands and Attentional Performance Dysfunction in Stabilized Schizophrenia Patients

et al. 2023

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Background and Objectives: Attentional dysfunction has long been viewed as one of the fundamental underlying cognitive deficits in schizophrenia. There is an urgent need to understand its neural underpinning and develop effective treatments. In the process of attention, neural oscillation has a central role in filtering information and allocating resources to either stimulus-driven or goal-relevant objects. Here, we asked if resting-state EEG connectivity correlated with attentional performance in schizophrenia patients. Materials and Methods: Resting-state EEG recordings were obtained from 72 stabilized patients with schizophrenia. Lagged phase synchronization (LPS) was used to measure whole-brain source-based functional connectivity between 84 intra-cortical current sources determined by eLORETA (exact low-resolution brain electromagnetic tomography) for five frequencies. The Conners’ Continuous Performance Test-II (CPT-II) was administered for evaluating attentional performance. Linear regression with a non-parametric permutation randomization procedure was used to examine the correlations between the whole-brain functional connectivity and the CPT-II measures. Results: Greater beta-band right hemispheric fusiform gyrus (FG)-lingual gyrus (LG) functional connectivity predicted higher CPT-II variability scores (r = 0.44, p < 0.05, corrected), accounting for 19.5% of variance in the CPT-II VAR score. Greater gamma-band right hemispheric functional connectivity between the cuneus (Cu) and transverse temporal gyrus (TTG) and between Cu and the superior temporal gyrus (STG) predicted higher CPT-II hit reaction time (HRT) scores (both r = 0.50, p < 0.05, corrected), accounting for 24.6% and 25.1% of variance in the CPT-II HRT score, respectively. Greater gamma-band right hemispheric Cu-TTG functional connectivity predicted higher CPT-II HRT standard error (HRTSE) scores (r = 0.54, p < 0.05, corrected), accounting for 28.7% of variance in the CPT-II HRTSE score. Conclusions: Our study indicated that increased right hemispheric resting-state EEG functional connectivity at high frequencies was correlated with poorer focused attention in schizophrenia patients. If replicated, novel approaches to modulate these networks may yield selective, potent interventions for improving attention deficits in schizophrenia.

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“…As to task-related functional MRI, many studies found a decreased activation of the dorsomedial prefrontal cortex, the supplementary motor area, and the right inferior frontal gyrus during tasks involving neurocognitive processes and of the right angular gyrus during social-cognitive tasks [ 24 ]. Concerning EEG, abnormalities were found in alpha, theta and gamma activity, as well as in mismatch negativity and P300 waves, and were associated with impairments in different neurocognitive domains such as attention, working memory, visual and verbal learning, and executive functioning [ 32 ]. Finally, PET studies assessing brain glucose metabolism with 18-fluorodeoxyglucose evidenced a hypometabolism in the frontal cortex without significant alterations in other brain regions [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Serotonin and Dopamine Activity Modulators in the Treatment of Negative Symptoms in Schizophrenia: A Rapid Review

et al. 2023

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Schizophrenia is among the fifteen most disabling diseases worldwide. Negative symptoms (NS) are highly prevalent in schizophrenia, negatively affect the functional outcome of the disorder, and their treatment is difficult and rarely specifically investigated. Serotonin-dopamine activity modulators (SDAMs), of which aripiprazole, cariprazine, brexpiprazole, and lumateperone were approved for schizophrenia treatment, represent a possible therapy to reduce NS. The aim of this rapid review is to summarize the evidence on this topic to make it readily available for psychiatrists treating NS and for further research. We searched the PubMed database for original studies using SDAM, aripiprazole, cariprazine, brexpiprazole, lumateperone, schizophrenia, and NS as keywords. We included four mega-analyses, eight meta-analyses, two post hoc analyses, and 20 clinical trials. Aripiprazole, cariprazine, and brexpiprazole were more effective than placebo in reducing NS. Only six studies compared SDAMs with other classes of antipsychotics, demonstrating a superiority in the treatment of NS mainly for cariprazine. The lack of specific research and various methodological issues, related to the study population and the assessment of NS, may have led to these partial results. Here, we highlight the need to conduct new methodologically robust investigations with head-to-head treatment comparisons and long-term observational studies on homogeneous groups of patients evaluating persistent NS with first- and second-generation scales, namely the Brief Negative Symptom Scale and the Clinical Assessment Interview for Negative Symptoms. This rapid review can expand research on NS therapeutic strategies in schizophrenia, which is fundamental for the long-term improvement of patients’ quality of life.

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Unveiling the Associations between EEG Indices and Cognitive Deficits in Schizophrenia-Spectrum Disorders: A Systematic Review

Cited by 15 publications

References 295 publications

Five-week music therapy improves overall symptoms in schizophrenia by modulating theta and gamma oscillations

Five-week music therapy improves overall symptoms in schizophrenia by modulating theta and gamma oscillations

Resting-State EEG Connectivity at High-Frequency Bands and Attentional Performance Dysfunction in Stabilized Schizophrenia Patients

Efficacy of Serotonin and Dopamine Activity Modulators in the Treatment of Negative Symptoms in Schizophrenia: A Rapid Review

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