Unveiling the antimicrobial potential of oxidized graphene derivatives: Promising materials for advanced wound dressings and antibacterial surfaces

Shirshahi, Vahid; Saedi, Mohammadamin; Nikbakht, Mohammad; Mirzaii, Mehdi

doi:10.1016/j.jddst.2023.104949

Cited by 1 publication

(2 citation statements)

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“…Our experimental tests assessing the antimicrobial properties of graphene with various functional groups demonstrated that the most potent antibacterial characteristics were observed in graphene when it was carboxylated and more oxidized (Saedi , 2022;Shirshahi et al, 2023). This experimental data validate the crucial role of functional groups in influencing the antibacterial effects of carboxylated and highly oxidized graphenes.…”

Section: Comparison Of Simulation Systemssupporting

confidence: 68%

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Interaction of functionalized graphene with cellular membranes: an in silico investigation of graphene-based nanovehicle toward biomedical applications

Gholami,

Zaboli,

Hashemzadeh

et al. 2024

Front. Nanotechnol.

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Nanomaterials, especially graphene derivatives, have become major tools in the biomedical area. Understanding the way that graphene interacts with component elements of biological systems, like biological membranes, is critical for the development of successful biomedical applications. The interaction mechanism of graphene sheets with a model cell membrane was investigated in this study using molecular dynamics (MD) simulations under three different conditions: pristine graphene (PG), carboxyl group-functionalized graphene (G-COOH), and amine group-functionalized graphene (G-NH2). The MD simulations demonstrated that functional groups on graphene surfaces improve their interaction with the head groups of the membrane. In 200 nanoseconds, PG reached equilibrium outside and near the phospholipid membrane. G-NH2 was positioned away from the model membrane’s surface, while G-COOH and G-NH2 also achieved equilibrium outside the membrane. It was shown by molecular dynamics simulations that after 200 ns, all three systems had attained their stable states. Crucially, it is discovered that the kind of functional groups greatly affected how the nanoparticles and membrane interacted. Each and every nanocarrier has a strong propensity to break through the membrane. The van der Waals interaction energies for the PG, G-NH2, and G-COOH systems were further shown by the obtained data to be roughly −400.66, −397.52, and −876.36 kJ/mol, respectively. These results support the notion that G-COOH interacts with the model cell bilayer more strongly than PG and G-NH2. This work highlights the influence of functional groups on the interaction of graphene sheets with biological membranes, offering important insights into the equilibrium behavior and entry mechanism of graphene sheets in a model cell membrane.

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Section: Comparison Of Simulation Systemssupporting

confidence: 68%

“…Standardized strains of all three microbes were used. The most effective antibacterial characteristics of graphene were found in its carboxylated and more oxidized form, according to the results of our antimicrobial tests (Saedi et al, 2022;Shirshahi et al, 2023).…”

Section: Introductionsupporting

confidence: 53%