Unveiling the Anticancer and Antibiofilm Potential of Catechin Overlaid Reduced Graphene Oxide/Zinc Oxide Nanocomposites

Nallasamy, Prakashkumar; Asik, Rajmohamed Mohamed; Kavitha, T.; Archunan, Govindaraju; Suganthy, Natarajan

doi:10.1007/s10876-021-02194-2

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…Catechin was proven to improve several medical conditions like obesity (Suzuki et al 2016), type-2 diabetes (Alipour et al 2018). It was also mentioned in many previous studies that catechin has antioxidant properties, which can protect several diseases like cancer, cardiovascular and neurodegenerative diseases, associated with reactive oxygen species (Bae et al 2020;Nallasamy et al 2021). This medicinally important polyphenolic compound can also act as an anti-infective agent (Shimamura et al 2007).…”

Section: Discussionmentioning

confidence: 94%

RP-HPLC based analysis of different polyphenols in seven species of Carex L. (Cyperaceae Juss.) from West Bengal, India

RAJAK

Ghosh

2022

Biodiversitas

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Abstract. Rajak P, Ghosh A. 2022. RP-HPLC based analysis of different polyphenols in seven species of Carex L. (Cyperaceae Juss.) from West Bengal, India. Biodiversitas 23: 2329-2341. Carex L. is one of the important genera of the family Cyperaceae having immense ecological significance and probable therapeutic potentiality due to the presence of bioactive phytochemicals i.e. polyphenols. RP-HPLC (reversed-phase high-performance liquid chromatography) based evaluation of polyphenols concerned with the chemotaxonomy of this genus, was a fundament of reported research but the evaluation of its therapeutic possibilities are still an open field of research. In concerned with the above aim, phytochemical investigation was done by analyzing the seven species of Indian Carexto to evaluate polyphenols employing RP-HPLC. The above-mentioned analysis reveals differences in the presence as well as the amount of these marker phytochemical components compositions of each and every studied species of Carex. Total of nine polyphenols was used as standard among which, except coumaric acid, all of the polyphenols were detected in considerable amount in the studied species. Among these seven species, Carex stramentitia Boott ex Boeckeler and C. alopecuroides D. Don were found to contain a higher number of polyphenols. Gallic acid was quantified in the highest amount in C. baccans Nees. A higher amount of phloroglucinol was also detected in C. insignis Boott and C. baccans. Remarkably, biochanin A, a highly significant therapeutic phytochemical, was only observed in higher amounts in C. alopecuroides.

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Section: Discussionmentioning

confidence: 94%

RP-HPLC based analysis of different polyphenols in seven species of Carex L. (Cyperaceae Juss.) from West Bengal, India

RAJAK

Ghosh

2022

Biodiversitas

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“…The absorbency was measured using an ELISA reader (Biochrom, UK) at 492 nm (test wavelength) in triplets. The results were reported as a percentage of multiplication in comparison to vehicle-treated cells [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

Zinc Oxide Nanoparticles as Diagnostic Tool for Cancer Cells

Ibraheem

Kadhim

et al. 2022

International Journal of Biomaterials

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ZnO nanoparticles have various characteristics that make them attractive to be used in many medical applications like a cancer diagnosis. It can be used as a nanoprobe for targeting different types of cancer cells in vitro as a cancer cell recognition system. The present study aims to investigate the permeability of ZnO NPs through both normal and cancerous cell lines in humans. In vitro experiments for ZnO NPs inside the environment of living cells have been described, which would contribute to the visualization of nanoparticles as cancer diagnostic and scanning techniques. MCF7, AMJ13, and RD cancer cells, and also the normal breast cell line HBL, were used in in vitro imaging experiments. The findings revealed that ZnO NPs specifically incorporated within tumor cells while accumulating less inside normal cells. Our findings show that ZnO NPs may be identified inside cancer cells after 1 h of exposure and can endure up to 3 h, providing them appropriate for tumor cell imaging. The findings showed that ZnO NPs might be employed as an alternate fluorophore for diagnostic imaging in the early identification of solid cancers. Therefore, here we studied in vitro applications of ZnO NPs and their beneficial use as a diagnostic tool for cancer cell lines rather than normal cells. Taken together, ZnO NPs can be used as good targeting NPs for the development of imaging agents for early diagnosis of cancers.

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“…This nanocomposite also showed strong reduction in biofilm formation (IC 50 5 ± 0.25 μg/mL), and disrupted biofilm architecture consisting of reduced microcolonies, mostly dead cells. The nanocomposite would be suitable for treatment of infectious disease and lung cancer [ 162 ]. The effects of selected nanomaterials are summarized in Table 1 .…”

Section: Gbns As Drugs and Nanocarriersmentioning

confidence: 99%

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Jampílek

Kráľová

2022

IJMS

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Climate change and increasing contamination of the environment, due to anthropogenic activities, are accompanied with a growing negative impact on human life. Nowadays, humanity is threatened by the increasing incidence of difficult-to-treat cancer and various infectious diseases caused by resistant pathogens, but, on the other hand, ensuring sufficient safe food for balanced human nutrition is threatened by a growing infestation of agriculturally important plants, by various pathogens or by the deteriorating condition of agricultural land. One way to deal with all these undesirable facts is to try to develop technologies and sophisticated materials that could help overcome these negative effects/gloomy prospects. One possibility is to try to use nanotechnology and, within this broad field, to focus also on the study of two-dimensional carbon-based nanomaterials, which have excellent prospects to be used in various economic sectors. In this brief up-to-date overview, attention is paid to recent applications of graphene-based nanomaterials, i.e., graphene, graphene quantum dots, graphene oxide, graphene oxide quantum dots, and reduced graphene oxide. These materials and their various modifications and combinations with other compounds are discussed, regarding their biomedical and agro-ecological applications, i.e., as materials investigated for their antineoplastic and anti-invasive effects, for their effects against various plant pathogens, and as carriers of bioactive agents (drugs, pesticides, fertilizers) as well as materials suitable to be used in theranostics. The negative effects of graphene-based nanomaterials on living organisms, including their mode of action, are analyzed as well.

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Unveiling the Anticancer and Antibiofilm Potential of Catechin Overlaid Reduced Graphene Oxide/Zinc Oxide Nanocomposites

Cited by 7 publications

References 41 publications

RP-HPLC based analysis of different polyphenols in seven species of Carex L. (Cyperaceae Juss.) from West Bengal, India

RP-HPLC based analysis of different polyphenols in seven species of Carex L. (Cyperaceae Juss.) from West Bengal, India

Zinc Oxide Nanoparticles as Diagnostic Tool for Cancer Cells

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

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