Unveiling STRs instability in a colorectal cancer FFPE sample: a case report
Giulia Soldati,
Chiara Saccardo,
Dario Raniero
et al.
Abstract:In forensic genetics, sometimes formalin-fixed paraffin-embedded (FFPE) biopsy material taken during life is the only biological sample available for individual identification or paternity testing. In most cases, this biological tissue is characterized by the presence of tumor cells characterized by instability and loss of heterozygosity of microsatellites (MSI/LOH) compared to the DNA present in cells of normal tissue.In this case report, two FFPE samples from the same male subject were available for genetic … Show more
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