2018
DOI: 10.1101/420091
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Unveiling Leishmania invasion of fibroblasts: calcium signaling, lysosome recruitment and exocytosis culminate with actin-independent invasion

Abstract: Intracellular parasites of the genus Leishmania are the causative agents of human leishmaniasis, a widespread emergent tropical disease. The parasite is transmitted by the bite of a hematophagous sandfly vector that inoculates motile flagellated promastigote forms into the dermis of the mammalian host. After inoculation, parasites are ultimately captured by macrophages and multiply as round-shaped amastigote forms. Macrophages seem not to be the first infected cells since parasites were observed invading neutr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2022
2022
2022
2022

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 38 publications
0
1
0
Order By: Relevance
“…Recently, this mechanism was elucidated using non-phagocytic cells as host cells and promastigote forms of the parasite. It was clearly demonstrated that L. amazonensis promastigotes actively induce cell invasion without any cytoskeleton activity, therefore, by a mechanism distinct from phagocytosis [75]. Similar to what was observed for Trypanosoma cruzi [76], the infection involves calcium signaling, recruitment, and exocytosis of lysosomes engaged in the process of plasma membrane repair and lysosome-triggered endocytosis.…”
Section: A Non-phagocytic Route Of Invasion For Leishmania Sppmentioning
confidence: 56%
“…Recently, this mechanism was elucidated using non-phagocytic cells as host cells and promastigote forms of the parasite. It was clearly demonstrated that L. amazonensis promastigotes actively induce cell invasion without any cytoskeleton activity, therefore, by a mechanism distinct from phagocytosis [75]. Similar to what was observed for Trypanosoma cruzi [76], the infection involves calcium signaling, recruitment, and exocytosis of lysosomes engaged in the process of plasma membrane repair and lysosome-triggered endocytosis.…”
Section: A Non-phagocytic Route Of Invasion For Leishmania Sppmentioning
confidence: 56%