Unveiling Ga(III) phthalocyanine—a different photosensitizer in neuroblastoma cellular model

Abstract

Phthalocyanines (Pc) and their metallated derivatives are strongly considered for photodynamic therapy (PDT) possessing unique properties as possible new photosensitizers (PS). We have used toxicological assessments, real‐time monitoring of cellular impedance, and imagistic measurements for assessing the in vitro dark toxicity and PDT efficacy of Ga(III)‐Pc in SHSy5Y neuroblastoma cells. We have established the non‐toxic concentration range of Ga(III)‐Pc, a compound which shows a high intracellular accumulation, with perinuclear distribution in confocal microscopy. By choosing Ga(III)Pc non‐toxic dose, we performed in vitro experimental PDT hampering cellular proliferation. Our proposed Ga(III)‐Pc could complete a future PS panel for neuroblastoma alternate therapy.

Carboranes as unique pharmacophores in antitumor medicinal chemistry

“… 164 Among these compounds, phthalocyanine (PC) has attracted much interest in cancer treatment due to its high singlet oxygen production capacity, high molar extinction coefficient, high optical stability, and strong near-infrared absorption capacity. 165 In this context, a water-soluble, o -carborane-derived PC complex ( 29 ) was designed and obtained by Hamuryudan and co-workers. 166 Carboranes served as the boron source of BNCT while PC played a role in PDT activation ( Figure 5 B).…”