“…In contrast, Cdc42 plays a major role in hyphal morphogenesis and establishment of hyphal polarity, while Rac1 is largely dispensable in A. nidulans [39,40]. Cdc42 is involved in diverse biological processes in filamentous fungi, such as polarity establishment in Penicillium marneffei [41], A. gossypii [10], Schizophyllum commune [42], and N. crassa [26], and growth or morphological development in U. maydis [27], Colletotrichum trifolii [43], C. purpurea [44], C. gloeosporioides [45], E. festucae [36], N. crassa [46], A. oligospora [18], F. graminearum [14], and B. cinerea [47], as well as cytokinesis [27], virulence [31,34,43,44,47], conidiation [14,34], germination [43,47], reactive oxygen species (ROS) production [18,31,32,34,43,45], and pyruvate metabolism [48]. However, the specific effects of Cdc42 on morphology and protein production in T. reesei have not been investigated.…”