Unusually large digitalis requirements

Luchi, Robert J.; Gruber, John W.

doi:10.1016/0002-9343(68)90049-1

Cited by 72 publications

(2 citation statements)

References 2 publications

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“…Stimuli were degraded at three levelslow, moderate, and high-by decreasing the object (slide-to-lens) distance for a fixed slide-to-screen distance (by blurring or defocusing the image). The power of a correcting lens, Pc, required to restore the image to the undegraded (focused) level at the same screen distance indexed the degree of image degradation (8). Phenomenally, the digits appeared almost focused at the low level, blurred at the moderate level, and highly blurred at the high level of image degradation.…”

mentioning

confidence: 99%

Digoxin-Inactivating Bacteria: Identification in Human Gut Flora

Saha

Butler

et al. 1983

Science

220

106

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Digoxin, the most widely used cardiac glycoside, undergoes significant metabolic conversion in many patients to cardioinactive metabolites in which the lactone ring is reduced. This appears to occur within the gastrointestinal tract. An attempt was made to isolate and identify the organisms capable of reducing digoxin from stool cultures obtained from human volunteers. Of hundreds of isolates studied, only Eubacterium lentum, a common anaerobe of the human colonic flora, converted digoxin to reduced derivatives. Such organisms were also isolated in high concentrations from the stools of individuals who did not excrete these metabolites when given digoxin in vivo. When the growth of E. lentum was stimulated by arginine, inactivation of digoxin was inhibited. Neither the presence of these organisms alone nor their concentration within the gut flora appeared to determine whether digoxin would be inactivated by this pathway in vivo.

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confidence: 99%

Digoxin-Inactivating Bacteria: Identification in Human Gut Flora

Saha

Butler

et al. 1983

Science

220

106

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“…Clark and Kalman [22] report recovery of dihydrodigoxin from urine of patients and volunteers in a significant number of patients. Lucchi and Griêer [23] also document the finding of this relatively cardioinactive metabolite from serum and urine of a patient with unusually large digoxin requirements. We have not identified this metabolite from any patient we studied, probably because it is relatively insoluble in chloroform, a prerequisite to ex traction by our reported techniques [24].…”

Section: Intravenous Administrationmentioning

confidence: 82%

Clinical Use of Digitalis Glycosides

Doherty¹

1985

Cardiology

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Digitalis glycosides continue to place high on the list of prescribed drugs. Digoxin is 8th on prescriptions written in the United States in 1980, digitoxin 16th, and digitalis leaf 23rd. There is little doubt that most physicians continue to believe these drugs are useful. The application of more definite indications, smaller doses, and the recognition of the role of pharmacokinetics and drug interactions make use of the glycosides more challenging than ever before in 1985.

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Digoxin Metabolism in Patients

Peters¹

1978

Arch Intern Med

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Unusually large digitalis requirements

Cited by 72 publications

References 2 publications

Digoxin-Inactivating Bacteria: Identification in Human Gut Flora

Digoxin-Inactivating Bacteria: Identification in Human Gut Flora

Clinical Use of Digitalis Glycosides

Digoxin Metabolism in Patients

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