Unusually High Calcaneal Speed of Sound Measurements in Children with Small Foot Size

Ramteke, Suman; Kaufman, Jonathan J.; Arpadi, Stephen M.; Shiau, Stephanie; Strehlau, Renate; Patel, Faeezah; Mbete, Ndileka; Coovadia, Ashraf; Yin, Michael T.

doi:10.1016/j.ultrasmedbio.2016.08.020

Cited by 4 publications

(2 citation statements)

References 11 publications

(11 reference statements)

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“…We excluded participants with SOS values ≥ 1625 m/s at either baseline or 12-months, as we have previously noted that such values represent spurious readings due to small foot size [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV

Roberts

Shen²,

Strehlau³

et al. 2022

PLoS ONE

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Children living with HIV (CLHIV) have decreased bone mineral content (BMC) and density (BMD), increasing risk for fracture and future osteoporosis. While DXA is the gold-standard for bone assessments, it lacks availability in resource-constrained settings (RCS). Quantitative ultrasound (QUS) offers an alternative owing to its portability, low cost, ease of handling, and lack of ionizing radiation. While QUS has detected reduced bone quality in CLHIV, the relationship between QUS and DXA in this population remains unexplored. At baseline and 12 months, BMC and BMD of the whole body, lumbar spine, and radius were measured by DXA in a longitudinal cohort of CLHIV in Johannesburg, South Africa. Calcaneal speed of sound (SOS) and broadband ultrasound attenuation (BUA) and radius SOS were obtained by QUS, and calcaneal stiffness index (SI) was calculated. Spearman correlations, with and without HIV stratification, were performed between QUS and DXA measurements at each visit and for absolute difference in measurements between visits. At baseline and 12-months, calcaneal BUA and SI displayed strong positive correlations with DXA, with only modest correlations between radial QUS and DXA at baseline. Longitudinal measures of QUS did not correlate with DXA. At both baseline and 12-months, individuals with DXA whole-body BMD z-score < -1 displayed significantly lower calcaneal BUA and SI. Cross-sectionally, calcaneal QUS correlates strongly with whole body DXA and may represent a viable diagnostic alternative in RCS. Longitudinally, the two methods do not correlate well, possibly reflecting that each method assesses distinct aspects of bone architecture.

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Section: Methodsmentioning

confidence: 99%

Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV

Roberts

Shen²,

Strehlau³

et al. 2022

PLoS ONE

Self Cite

View full text Add to dashboard Cite

show abstract

“…Serum bone-specific alkaline phosphatase and C-terminal collagen crosslinks (a collagen degradation product released during bone resorption) directly measure metabolic bone turnover but the clinical utility of these measures to monitor BMD in young HIV-infected children is uncertain and they are prohibitively expensive if utilized on a large scale [67]. It is unclear whether BMD assessment by calcaneal quantitative ultrasound has a place in routine surveillance; some studies find it helpful [68] and others not [69]. Delayed bone age (by plain radiography) is associated with reduced BMD (by DXA) and may be useful as a crude screening tool in individuals whose epiphyses have not yet fused [70].…”

Section: Introductionmentioning

confidence: 99%