Unusual van Deemter plots of optical isomers on a chiral brush-type liquid chromatography column

Boteva, A. A.; Красных, О. П.; Stepanova, Maria V.; Ali, Imran

doi:10.1016/j.chroma.2019.01.048

Cited by 16 publications

(3 citation statements)

References 41 publications

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“…Noticeably, the enantioresolution of these systems was very large even at the highest flow-rates, at the point that the bottleneck to the attainment of even more sensational results has been the well-known pressure/flow-rate trade-off, even by using modern UHPLC equipment. Despite the achievement of these milestones, only a few studies aimed at investigating the fundamentals of mass transfer in chiral LC have been attempted [13,14].…”

Section: Introductionmentioning

confidence: 99%

Mass transfer kinetics on modern Whelk-O1 chiral stationary phases made on fully- and superficially-porous particles

Felletti

Catani

Mazzoccanti

et al. 2021

Journal of Chromatography A

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Section: Introductionmentioning

confidence: 99%

Mass transfer kinetics on modern Whelk-O1 chiral stationary phases made on fully- and superficially-porous particles

Felletti

Catani

Mazzoccanti

et al. 2021

Journal of Chromatography A

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“…The unusual dynamic behavior of the enantiomers of pyrroloquinolones was studied on a Nautilus-R column under RP conditions [ 59 ]. A phenomenological explanation was provided for the observed differences between the van Deemter plots of the enantiomers.…”

Section: Recent Applications Of Different Macrocyclic Antibiotic-based Cspsmentioning

confidence: 99%

Enantioselective Liquid Chromatographic Separations Using Macrocyclic Glycopeptide-Based Chiral Selectors

et al. 2021

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Numerous chemical compounds of high practical importance, such as drugs, fertilizers, and food additives are being commercialized as racemic mixtures, although in most cases only one of the isomers possesses the desirable properties. As our understanding of the biological actions of chiral compounds has improved, the investigation of the pharmacological and toxicological properties has become more and more important. Chirality has become a major issue in the pharmaceutical industry; therefore, there is a continuous demand to extend the available analytical methods for enantiomeric separations and enhance their efficiency. Direct liquid chromatography methods based on the application of chiral stationary phases have become a very sophisticated field of enantiomeric separations by now. Hundreds of chiral stationary phases have been commercialized so far. Among these, macrocyclic glycopeptide-based chiral selectors have proved to be an exceptionally useful class of chiral selectors for the separation of enantiomers of biological and pharmacological importance. This review focuses on direct liquid chromatography-based enantiomer separations, applying macrocyclic glycopeptide-based chiral selectors. Special attention is paid to the characterization of the physico-chemical properties of these macrocyclic glycopeptide antibiotics providing detailed information on their applications published recently.

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“…HPLC based on chiral stationary phases (CSPs) has become one of the most attractive approaches to chiral separations due to its simplicity, speed and selectivity [3][4][5]. Due to the high column efficiency and column capacity, the Brush-type CSPs has been widely used in the field of medicine [6,7]. Silica, was always utilized as the carrier of the Brush-type CSPs.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Tens-micron-sized Functionalized Polystyrene Microspheres for Utilization in Chiral Drug Isolation

et al. 2020

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Unusual van Deemter plots of optical isomers on a chiral brush-type liquid chromatography column

Cited by 16 publications

References 41 publications

Mass transfer kinetics on modern Whelk-O1 chiral stationary phases made on fully- and superficially-porous particles

Mass transfer kinetics on modern Whelk-O1 chiral stationary phases made on fully- and superficially-porous particles

Enantioselective Liquid Chromatographic Separations Using Macrocyclic Glycopeptide-Based Chiral Selectors

Fabrication of Tens-micron-sized Functionalized Polystyrene Microspheres for Utilization in Chiral Drug Isolation

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