Unusual Thyroid Scintigrams in Plummerʼs Disease During Methimazole Therapy Conversion of Hot to Hypofunctional Nodules

Tamai, Hiroshi; Nagai, Kazuyuki; Ishimoto, Junko; Matsubayashi, Sunao; Matsuzuka, Fumio; Miyauchi, Akira; Kuma, Kanji; Nagataki, Shigenobu

doi:10.1097/00003072-199007000-00002

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1997

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“…It is conceivable that the hot nodule in the present case was functionally suppressed after the administration of T3 due to its dependence on TSH. It is of interest that the hot nodule in the present case became relatively hypofunctioning compared with extranodular tissues after MMI treatment as reported previously [11]. Uneven distribution of MMI between nodular and extranodular tissues may explain this phenomenon as due to the greater blood flow in the nodule than that in non-nodular thyroid tissues [12].…”

Section: Discussionsupporting

confidence: 57%