Unusual seedless approach to gold nanoparticle synthesis: application to selective rapid naked eye detection of mercury(<scp>ii</scp>)

Sukeri, Anandhakumar; Rajaram, Rajendran; Mathiyarasu, J.

doi:10.1039/c4an00480a

Cited by 27 publications

(31 citation statements)

References 30 publications

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“…21 The reduction potential of Au(I) is higher than that of Au(III), which increases the thermodynamic favorability of zerovalent gold ion or Au(0) formation. 22,23 These Au The observed color is caused by the ligand exchange of Clin AuCl 4…”

Section: Resultsmentioning

confidence: 99%

Hydrogel Nanosensors for Colorimetric Detection and Dosimetry in Proton Beam Radiotherapy

Inamdar

Pushpavanam

Lentz

et al. 2018

ACS Appl. Mater. Interfaces

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Proton beam therapy (PBT) is a state-of-the-art radiotherapy treatment approach that uses focused proton beams for tumor ablation. A key advantage of this approach over conventional photon radiotherapy (XRT) is the unique dose deposition characteristic of protons, which results in superior healthy tissue sparing. This results in fewer unwanted side effects and improved outcomes for patients. Currently available dosimeters are intrinsic, complex, and expensive and are not routinely used to determine the dose delivered to the tumor. Here, we report a hydrogel-based plasmonic nanosensor for detecting clinical doses used in conventional and hyperfractionated proton beam radiotherapy. In this nanosensor, gold ions, encapsulated in a hydrogel, are reduced to gold nanoparticles following irradiation with proton beams. Formation of gold nanoparticles renders a color change to the originally colorless hydrogel. The intensity of the color can be used to calibrate the hydrogel nanosensor in order to quantify different radiation doses employed during proton treatment. The potential of this nanosensor for clinical translation was demonstrated using an anthropomorphic phantom mimicking a clinical radiotherapy session. The simplicity of fabrication, detection range in the fractionated radiotherapy regime, and ease of detection with translational potential makes this a first-in-kind plasmonic colorimetric nanosensor for applications in clinical proton beam therapy.

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Section: Resultsmentioning

confidence: 99%

Hydrogel Nanosensors for Colorimetric Detection and Dosimetry in Proton Beam Radiotherapy

Inamdar

Pushpavanam

Lentz

et al. 2018

ACS Appl. Mater. Interfaces

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“…The UV-Vis spectra of these suspensions are compared with the spectra of starting precursors, aqueous AgNO 3 and AuCl 3 solutions in Fig.5. While the UV-Vis spectrum of AuCl 3 aqueous solution exhibits a single peak at 290 nm, which may arise due to ligand-metal charge transfer [30]; the UV-Vis spectrum of Au-CTAB suspension has two peaks at 259 and 393 nm. The absorption peak at 259 nm can be assigned to the vibrational frequencies of [AuBr 2 ] ¯, while the peak at 393 nm confirms the formation of complex of cetyltrimethylammonium ion (CTA + ) with [AuBr 4 ] ¯([CTA] + [AuBr 4 ]¯) [31].…”

Section: Uv-vis Analysis Of Au Ag Containing Ctab Gels and Au Ag Namentioning

confidence: 99%

Fast and facile preparation of CTAB based gels and their applications in Au and Ag nanoparticles synthesis

Upadhyay

Soin

Saha

et al. 2015

Materials Chemistry and Physics

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“…The recommended mechanism suggests a two-step process, i.e., nucleation and the successive growth of the particles. 39 Von Eschwege et al 40 have extensively studied the oxidation products of dithizone. The nanoclusters thus formed act as nucleation centers and catalyze the reduction process of the remaining metal ions present in the bulk which thus results in autocatalytic growth.…”

Section: Resultsmentioning

confidence: 99%

Photochemically mediated synthesis of a gold colloid by dithizone and its application in the amperometric sensing of thiocyanate

Gupta

Prakash

2015

RSC Adv.

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This paper highlights a one-step facile approach for the photochemically assisted synthesis of stable gold colloids (Au) using dithizone (DTZ) without any extra controls, viz. surfactant, seeds, pH etc. Although dithizone chemistry has been documented extensively in scientific reports, it is amazing to note that there are scarcely any reports published so far on the photochemically mediated formation of gold nanostructures using dithizone. The as-prepared electroactive hybrid nanomaterial was extensively investigated using various characterization techniques, including UV-visible spectroscopy, FT-IR, cyclic voltammetry, amperometry, TEM, FESEM and XPS. The formation of the gold nanostructure over time by exposure to light using dithizone was ascertained, with the results complemented by time dependent UV-visible as well as TEM studies. A conceivable reaction mechanism for the formation of the gold nanostructure has also been proposed. The use of dithizone as a reductant as well as a stabilizer offers great advantages in terms of simplicity during synthesis, i.e., a one-pot synthesis, use of aqueous/organic media, no external reducing agent and a very limited post-synthesis work-up. Furthermore, an electroactive advanced hybrid nanomaterial derived from nanoscale gold protected with dithizone (DTZ) and its oxidation product (DTZH) has been utilized for the amperometric sensing of hazardous thiocyanate. The modified electrode with the hybrid material efficiently electrocatalyzes the oxidation of thiocyanate at a potential of 0.55 V vs. AgCl/Ag and shows a linear response toward thiocyanate sensing with a sensitivity of 0.016 mA nM À1 and a limit of detection of 23.348 nM at a S/N (signal-to-noise ratio) of 3. The electrochemistry behind the sensing of thiocyanate is possibly due to electrostatic interactions (DTZH/SCN nÀ /Au m+ /SCN nÀ /DTZH complexation) and the conducting gold nanoparticles facilitating the efficient collection and transfer of electrons to the modified electrode.

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Unusual seedless approach to gold nanoparticle synthesis: application to selective rapid naked eye detection of mercury(ii)

Cited by 27 publications

References 30 publications

Hydrogel Nanosensors for Colorimetric Detection and Dosimetry in Proton Beam Radiotherapy

Hydrogel Nanosensors for Colorimetric Detection and Dosimetry in Proton Beam Radiotherapy

Fast and facile preparation of CTAB based gels and their applications in Au and Ag nanoparticles synthesis

Photochemically mediated synthesis of a gold colloid by dithizone and its application in the amperometric sensing of thiocyanate

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