Unusual relationship between skin lesions and esophageal cancer: a case report and review of literature

Racionero, Francisca Moreno; Asenjo, Beatriz De Andrés; Nunez, Marie; Moran, Patrick L.; Ortega-Loubón, Christian; Jiménez, José Rabadán; Rentería, Juan Beltrán de Heredia

doi:10.1055/s-0034-1398791

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…Only five cases of cutaneous metastases are described in the literature, secondary to esophageal adenocarcinoma, which rarely metastasizes to the skin. The predisposition of these masses is on the scalp and they appear as painful cutaneous nodules, asymptomatic at first [73][74][75]. The presence of cutaneous metastasis was also described on the face as a small mobile painless nodule [76].…”

mentioning

confidence: 99%

Differential Diagnosis in Esophageal Cancer. Review on literature

Popa¹,

Badiu²,

Andronache³

et al. 2019

Rev. Chim.

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Esophageal cancer represents a neoplasm that is thought to have both an increased incidence and prevalence in the following years. Although much progress has been made in the detection and the early treatment of esophageal cancer, the prognosis is still limited, and mortality remains very high. The most common histological types of esophageal cancer are squamous cell carcinoma, and, respectively, adenocarcinoma. Lately, there has been an accelerated increase in the incidence of adenocarcinoma, in the context of increased prevalence of gastro-esophageal reflux disease and obesity, but also of the current alimentary diet, especially in developed countries. The esophagus has its anatomical features. Moreover, it is located topographicallyin a complex cervico-thoraco-abdominal area, unique for a viscus. From the clinical point of view, the onset of symptoms of esophageal cancer is insidious. For these reasons, special attention should be pain in the early detection and differentiation of this neoplasm from other pathologies. These pathologies are very varied and may comprise other esophageal diseases, neighborhood pathologies such as cervical, thoracic, abdominal, systemic pathologies (immunologic, infectious) or other pathologies such as the oro-maxillo-facial, oculo-orbital, vascular, muscular, and cutaneous ones. Keywords: esophagus, cancer, differential diagnosis

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mentioning

confidence: 99%

Differential Diagnosis in Esophageal Cancer. Review on literature

Popa¹,

Badiu²,

Andronache³

et al. 2019

Rev. Chim.

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“…The skin lesions may be observed in different parts of the human body. Most commonly this would be in the scalp [ 14 ], and head and neck locations were more common than abdominal, pelvic, thoracic, extremity or other skin locations. Only six cases of esophageal adenocarcinoma were reported to metastasize to multiple skin and muscle sites.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Esophageal Adenocarcinoma Presenting as Neck Dermal Metastasis

Ibrahim-Shaikh,

Shaikh,

Daboul

et al. 2024

Case Reports in Dermatological Medicine

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Dermal metastasis is a rare manifestation of visceral disease, and esophageal adenocarcinomas represent around only 1% of primaries that present with cutaneous metastasis. In this case, we discuss a patient who presented with a painless submental mass and extensive right neck cutaneous induration and erythema. Core needle biopsy demonstrated poorly differentiated adenocarcinoma. Blood testing also demonstrated elevated carbohydrate antigen 19-9, carcinoembryonic antigen, and alkaline phosphatase. PET/CT followed by esophagoscopy led to the diagnosis of esophageal signet-cell adenocarcinoma primary with isolated dermal metastasis. The patient was started on palliative radiotherapy and passed away two months later from a suspected thoracic fistula and hydropneumothorax.

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“…We searched PubMed using the keywords “Esophageal adenocarcinoma AND unusual metastasis OR metastases AND case reports,” and this search yielded three detailed case reports. One such case reported the metastasis of EAC to the skin in which the tumor metastasized to the skin of the head, neck, and abdominal region [ 13 ]. Other cases of unusual metastasis were EAC with metastasis to the prostatic urethra [ 14 ] and the urinary bladder [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Esophageal Adenocarcinoma: An Unusual Pericardial and Pulmonary Metastasis – A Case Report

Rasheed,

Usman,

Rehman

et al. 2023

Case Rep Oncol

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Introduction: Esophageal adenocarcinoma (EAC) manifests in the glandular cells present in the lining of the esophagus and usually forms in the distal portion of the esophagus. The metastasis of EAC has been reported to occur in surrounding lymphovascular structures, the liver, brain, and bones. Case Presentation: We present the rare case of a 52-year-old Hispanic male with EAC metastasis to the pericardium and lungs. The patient presented with shortness of breath off and on for the last 6 weeks without any usually reported symptoms of EAC like chest pain, vomiting, or chronic cough. Respiratory examinations of this patient were significant for bilateral bronchial breathing and coarse crackles. The patient had been given numerous courses of oral antibiotics over the previous weeks with the provisional diagnosis of atypical pneumonia. Cardiac tamponade pathophysiology was also observed in this patient, for which a pericardial window was created to relieve the patient’s symptoms. A final diagnosis of EAC with an unusual metastasis in the lungs and pericardium was made based on radiological and pathological findings. The patient chose palliative care instead of curative care because of the advanced stage of this cancer. The patient received cancer diagnosis counseling and was sent to hospice care for further management. Conclusion: The metastasis of EAC to the pericardium and lungs instead of usual sites constitutes an important prognostic factor in the overall survival of patients.

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Unusual relationship between skin lesions and esophageal cancer: a case report and review of literature

Cited by 6 publications

References 19 publications

Differential Diagnosis in Esophageal Cancer. Review on literature

Differential Diagnosis in Esophageal Cancer. Review on literature

Metastatic Esophageal Adenocarcinoma Presenting as Neck Dermal Metastasis

Esophageal Adenocarcinoma: An Unusual Pericardial and Pulmonary Metastasis – A Case Report

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