Unusual regioselective reaction of 2,6-dichloro-4-methylnicotinonitrile with malononitrile dimer

Synthesis and Aminomethylation of 2-Amino-4-(2-chlorophenyl)-6-(dicyanomethyl)-1,4-dihydropyridine-3,5-dicarbonitrile N-Methylmorpholinium Salt

“…Continuing our research in the field of malononitrile dimer chemistry [24][25][26][27][28], we obtained new functional 2-(dicyanomethyl)pyridine derivatives and studied their properties. It has been previously shown that 2-cyanothioacrylamides can react with malononitrile dimer in the presence of bases to eliminate hydrogen sulfide and form dicyanomethanides 5 (Ar = 2-IC 6 H 4 ) and 7 (Scheme 2) [13,17].…”

Methylene Components Exchange in the Reaction of Cyanoacetohydrazide with 2-Amino-4-arylbuta-1,3-diene-1,1,3-tricarbonitriles

“…Malononitrile dimer (2-aminoprop-1-ene-1,1,3-tricarbonitrile, 10) is a reactive multifunctional reactant widely used in organic synthesis (see reviews [24,25]). Continuing studies in the field of heterocyclization reactions of malononitrile dimer [26][27][28][29][30][31][32], herein we studied the reaction of arylmethylidene derivatives of malononitrile dimer 11 with cyanoacetohydrazide 1. Compounds 11 are successfully used in organic synthesis to obtain a wide range of heterocyclic products such as furo [3,2-c]isothiazole and isoselenazole [33,34], 3-azabicyclo[3.1.0]hexane [35], 2-bromonicotinonitrile derivatives [36], new merocyanine dyes with an isoindole fragment [37], pyrido [2,3-d]pyrimidines [38], etc.…”