Unusual presentation of primary klebsiella meningitis: successful treatment with cefotaxime

Sandyk, Reuven; Brennan, Michael J.

doi:10.1136/pgmj.59.690.256

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…Underlying co-morbidities included diabetes, alcoholism and chronic liver disease[ 1 - 4 ]. Outside Taiwan, cases of K. pneumoniae meningitis have occurred, predominantly in other parts of Asia [ 5 - 7 ] but also in Europe [ 8 - 11 ] and North America [ 12 - 14 ]. The rarity of these cases outside Asia raises the possibility of ethnicity or country of origin predisposing individuals to invasive disease[ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Community-acquired Klebsiella pneumoniae meningitis in an alcoholic patient with an infected pancreatic pseudocyst; a case report and review of literature

et al. 2007

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We report a case of a 49-year-old male with a history of chronic alcoholism and evidence of a pancreatic pseudocyst on CT scanning. He presented with a 3-days history of fever, loss of appetite and upper abdominal pain. Blood cultures grew Klebsiella pneumoniae and he improved clinically with a seven-day course of intravenous co-amoxiclav and metronidazole. Two weeks later he was readmitted to hospital with impaired consciousness and septic shock, and died three days later in intensive care. Post mortem examination revealed bacterial meningitis and an infected pancreatic pseudocyst. Klebsiella pneumoniae was isolated from the pancreas and meninges.

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Section: Discussionmentioning

confidence: 99%

Community-acquired Klebsiella pneumoniae meningitis in an alcoholic patient with an infected pancreatic pseudocyst; a case report and review of literature

et al. 2007

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Unusual presentation of pyogenic meningitis in a diabetic

McCann

1985

Pract Diab Int

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A 53‐year old man with maturity‐onset diabetes mellitus presented with a gram negative septicaemia after a preceding period of 2–3 weeks malaise. There were no localising features to suggest the infective origin on physical examination or investigation and he was treated with intravenous ampicillin, gentamicin and cefuroxime. He died within 48 hours and a post‐mortem demonstrated an unsuspected pyogenic meningitis, shown after culture of cerebrospinal fluid to be due to Klebsiella pneumoniae.

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Initial Chemotherapy for Purulent Meningitis in Children

Kobayashi

1986

Pediatrics International

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The combination of ampicillin with either gentamicin or chloramphenicol, which is currently the initial chemotherapy for purulent meningitis, has lost its effectiveness in recent years because of an increase in the incidence of ampicillin-resistant strains. This has made it necessary to search for a suitable substitute therapy.Twenty-two new P-lactam agents were compared with penicillin G and ampicillin in terms of their antibacterial activity in relation to the principal causative microbes of meningitis and their ability to transfer into the cerebrospinal fluid (CSF) of rabbits with experimental staphylococcal meningitis. In addition, a survey was conducted of the therapeutic efficacy achieved by these drugs in cases seen by the authors and in other domestic and overseas cases. Finally, an investigation was made as to whether or not the transfer of the drug into the CSF was suppressed when it was administered simultaneously with ampicillin.From the results, it was surmised that in future the most appropriate initial chemotherapy for purulent meningitis will be a combination of cefotaxime, or perhaps ceftriaxone, plus ampicillin.

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Unusual presentation of primary klebsiella meningitis: successful treatment with cefotaxime

Cited by 4 publications

References 5 publications

Community-acquired Klebsiella pneumoniae meningitis in an alcoholic patient with an infected pancreatic pseudocyst; a case report and review of literature

Community-acquired Klebsiella pneumoniae meningitis in an alcoholic patient with an infected pancreatic pseudocyst; a case report and review of literature

Unusual presentation of pyogenic meningitis in a diabetic

Initial Chemotherapy for Purulent Meningitis in Children

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