Unusual Presentation of Gianotti-Crosti Syndrome due to Epstein-Barr Virus Infection

Dhaheri, Hind Saif Al; Kaabi, Amani Al; Hamo, Yasmin Kara; Kaabi, Aysha Al; Kaabi, Salwa Al; Tatari, Hossam Al

doi:10.1155/2016/1017524

Cited by 10 publications

(16 citation statements)

References 4 publications

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“…It is a relatively common condition worldwide, but frequently remains underdiagnosed. It appears most commonly in infants between 1 and 6 years old, however similar cases were described in adults [ 1 , 4 ]. Studies showed that GCS occurred more frequently during spring and summer and in patients with personal or family history of atopy [ 5 , 6 ].…”

Section: Discussionmentioning

confidence: 90%

A Case of Recurrent vaccine-triggered Gianotti–Crosti Syndrome

et al. 2021

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Section: Discussionmentioning

confidence: 90%

A Case of Recurrent vaccine-triggered Gianotti–Crosti Syndrome

et al. 2021

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“…We found 264 studies related to the possible cutaneous and mucosal manifestations during EBV acute infection; we selected the articles that more exhaustively reported the clinical and laboratory description of the case/cases, 5‐45 published from 1954 to 2018 (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Dermatological manifestations of Epstein‐Barr virus systemic infection: a case report and literature review

et al. 2020

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Epstein-Barr virus (EBV) is a human herpesvirus spread in childhood by contact with saliva. In all populations, the great majority of people are infected by middle age. EBV can cause asymptomatic infection, nonspecific symptoms or, especially in adolescents and young adults, the infectious mononucleosis (IM), characterized by pharyngitis, lymphadenopathy, fatigue, and fever. Two main types of skin rashes, accounted as atypical exanthems, occur in patients with acute IM: a faint erythematous maculopapular eruption of 24-48 hours duration (5-15% of the patients) or a pruritic maculopapular rash in almost all patients receiving ampicillin or amoxicillin. Moreover EBV acute infection has been related to other cutaneous manifestations, such as Gianotti-Crosti syndrome, unilateral laterothoracic exanthem (especially in children), and others. In this study, we reported a case of atypical exanthem with an erythematous-papulovesicular pattern in a 22-year-old female patient with IM and performed a review of the literature of the cutaneous and mucosal eruptions occurring during EBV acute infections.

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“…The immunopathogenic mechanism of GSC is still obscure. While historically thought to be a manifestation of hepatitis B infection, the association with various viral agents (Coxsackie, CMV, enteroviruses, parvovirus B19, poxvirus, rotavirus, rubella, hepatitis A virus, HSV-1) has been reported and, not rarely, GCS has been described following vaccination (3)(4)(5)(6). This suggest a role of an immunologic response to viral antigens rather than a primary manifestation of infection.…”

Section: Discussionmentioning

confidence: 99%

“…Although often asymptomatic, the lesions may be mildly to moderately pruritic. It is known or suspected to be associated with many viral infections, such as Hepatitis B virus, Cytomegalovirus, Coxsackie, Adenovirus, Influenza and, more frequently, Epstein-Barr virus (3,4). Recent immunizations are often described in association to GCS (5,6).…”

Section: Introductionmentioning

confidence: 99%

The Serum Immunoglobulin E Level: Is There a Relationship With the Clinical Course of the Gianotti-Crosti Syndrome?

et al. 2021

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Background: Gianotti Crosti syndrome (GCS) is a self-healing condition with a spontaneous resolution in 2–6 weeks but, even if rarely, recurrent episodes have been reported.Objective: The aim of this observational study is to investigate serum Immunoglobulin E (IgE) level in children with GCS, evaluating if there is a relationship between IgE level and clinical course of the disease.Methods: Children with GCS diagnosed at a tertiary care children's university hospital between June 2018 and November 2019 were prospectively enrolled. Demographic, clinical and hematochemical data of children investigated were collected. In particular, IgE level were investigated at symptoms onset and, if available, at the following blood tests. Patients were divided in 2 groups on the bases of the clinical course: children with a chronic relapsing course and children who did not present any relapse.Results: Among 29 patients enrolled in this study, 14 (48.3%) children had a chronic relapsing course and 15 (51.7%) did not present any relapse. A statistically significant difference was present considering the length of the disease: 210 days (IQR: 161.25–255) for patients with a chronic relapsing course compared to 40 days (IQR: 30–75) for the other group (p < 0.0001). About the median IgE level in the 2 groups, a value about 10 time higher was found in children with chronic course compared to the other group (1,144 vs. 116 U/mL) with a statistically significant difference (p < 0.0001).Conclusion: Despite the study limitations, a significant correlation between higher IgE levels and chronic-relapsing course of the GCS can be assumed.

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Unusual Presentation of Gianotti-Crosti Syndrome due to Epstein-Barr Virus Infection

Cited by 10 publications

References 4 publications

A Case of Recurrent vaccine-triggered Gianotti–Crosti Syndrome

A Case of Recurrent vaccine-triggered Gianotti–Crosti Syndrome

Dermatological manifestations of Epstein‐Barr virus systemic infection: a case report and literature review

The Serum Immunoglobulin E Level: Is There a Relationship With the Clinical Course of the Gianotti-Crosti Syndrome?

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