Unusual Presentation of Gastric Outlet Obstruction Due to Breast Cancer Metastasis: A Case Report

Mohy-ud-din, Nabeeha; Patek, Bonnie; Dhawan, Manish

doi:10.7759/cureus.4533

Cited by 4 publications

(8 citation statements)

References 7 publications

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“…6 Deep biopsies should be performed using endoscopy or endoscopic ultrasoundguided biopsies if necessary. 10 In our study, the endoscopic findings were varied. Some patients (Patients 1, 3, and 4) only showed a nodule or abnormalities of part of the mucosa.…”

Section: Endoscopic Evaluationmentioning

confidence: 72%

“…There are also some unusual presentations, such as gastric outlet obstruction and gastric perforation, which are pathologically confirmed as gastric metastasis from breast cancer. 10,11…”

Section: Discussionmentioning

confidence: 99%

“…6 Deep biopsies should be performed using endoscopy or endoscopic ultrasound-guided biopsies if necessary. 10…”

Section: Discussionmentioning

confidence: 99%

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Gastric metastasis from breast cancer: five cases and a single-institutional review

Cheng,

Jia,

Zhang

et al. 2024

J Int Med Res

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Gastric metastasis from breast cancer has a high rate of misdiagnosis and missed diagnosis. Data of patients who had gastric metastasis from breast cancer were retrieved from our hospital between 2014 and 2020. The gastric metastasis from breast cancer incidence was 0.04% (5/14,169 cases of breast cancer). Four patients had invasive lobular carcinoma, and the other patient had invasive ductal carcinoma. The time from the initial diagnosis of breast cancer to the appearance of gastric metastasis ranged from 0 to 12 years. One patient’s endoscopic presentation was similar to mucosal-associated lymphoid tissue lymphoma and presented with gastric mucosal congestion and edema, widened wrinkles, mixed color fading, and redness. The initial pathological diagnosis of this patient was mucosal-associated lymphoid tissue lymphoma, and breast cancer was finally confirmed by immunohistochemistry. Hormonal receptors were highly expressed in four patients with primary and metastasis lesions and were negative in one patient. Human epidermal growth factor receptor 2 was negative in all patients. Mammaglobin and GATA3 were positive in all patients. In conclusion, the gastric metastasis of breast cancer incidence rate is low, and misdiagnosis can lead to insufficient or excessive treatment. Multiple biopsies and immunohistochemistry should be performed to diagnose gastric metastasis of breast cancer.

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Section: Endoscopic Evaluationmentioning

confidence: 72%

“…There are also some unusual presentations, such as gastric outlet obstruction and gastric perforation, which are pathologically confirmed as gastric metastasis from breast cancer. 10,11…”

Section: Discussionmentioning

confidence: 99%

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Gastric metastasis from breast cancer: five cases and a single-institutional review

Cheng,

Jia,

Zhang

et al. 2024

J Int Med Res

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“…Finally, there were approximately 32 cases of gastrointestinal metastases of breast carcer. [ 11 – 42 ] The patient's information was summarized in Table 1 and the clinicopathological features were analyzed in Table 2 . The mean age of the patients with gastrointestinal metastases was 62.75 years (range: 39–84).…”

Section: Discussionmentioning

confidence: 99%

Widespread Metastasis to the Stomach 10 Years After Primary Breast Cancer

Fu¹,

Zou²,

Long-Li³

et al. 2020

Medicine

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Rationale: Breast cancer is a common malignant tumor. The most common metastatic sites of breast cancer are the bone, brain, liver and lung, and gastrointestinal metastases are rare. Considering that the median time interval from the initial breast cancer diagnosis to stomach metastasis is 77.5 months, gastrointestinal metastases are rarely observed 10 years after primary breast cancer. Patient concerns: Here, we present a 63-year-old female with unusual endoscopy results that revealed scattered polyps and mucosal infiltration throughout the stomach, which were later confirmed to be metastatic lobular carcinoma of the breast that had been surgically removed 10 years earlier. Diagnosis: The patient was diagnosed with gastric metastases of breast cancer by immunohistochemistry. Interventions: The patient underwent endocrine therapy with palbociclib and tamoxifen. Outcomes: After 1 year of endocrine therapy, the symptoms of upper abdominal discomfort and fatigue were relieved and a new gastroscopy revealed there had been no significant progression of the gastric metastasis. According to the Response Evaluation Criteria in Solid Tumors (RECIST), the patient reached a state of stable disease. Lessons: Gastric metastases of breast cancer are rare in the clinical setting. However, considering the possibility of gastric metastases from breast cancer and performing an upper endoscopy are crucial for patients who present with any subtle gastric symptoms and have a past medical history of breast cancer, even if the breast cancer occurred more than 10 years ago.

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“…The histological subtype that most commonly develops GI metastasis is lobular breast cancer. Lobular breast cancer, which constitutes 5-10% of all breast cancers, more frequently tends to be metastatic to uncommon sites such as the GI tract, ovaries, or peritoneum when compared to ductal carcinoma [13].…”

Section: Discussionmentioning

confidence: 99%

Secondary Alopecia Neoplastica Mimicking Alopecia Areata following Breast Cancer

et al. 2020

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Cutaneous metastases from visceral carcinomas are relatively uncommon, with an overall incidence ranging from 0.7 to 9%. Diagnosis of scalp metastases usually escapes clinicians and dermatologists due to the fact that these metastases are mimicking other benign dermatological conditions. Herein, we present an uncommon case of scalp alopecia neoplastica mimicking alopecia areata due to breast cancer; a 43-year-old woman diagnosed with lobular cancer 3 years previously presented with acute loss of hair in well-circumscribed areas of the scalp and was diagnosed with alopecia areata by a private-practice dermatologist. She was then reevaluated, and due to her history of breast cancer, a biopsy from the scalp was performed and revealed alopecia neoplastica. At the same time that the skin lesions were recognized as disease involvement, the patient presented with dyspepsia, and endoscopy of the upper and lower gastrointestinal tract also revealed metastasis to the stomach and bowel. Gastrointestinal metastasis may occur with several types of cancer, but the stomach and bowel are rare metastatic sites for breast cancer.

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Unusual Presentation of Gastric Outlet Obstruction Due to Breast Cancer Metastasis: A Case Report

Cited by 4 publications

References 7 publications

Gastric metastasis from breast cancer: five cases and a single-institutional review

Gastric metastasis from breast cancer: five cases and a single-institutional review

Widespread Metastasis to the Stomach 10 Years After Primary Breast Cancer

Secondary Alopecia Neoplastica Mimicking Alopecia Areata following Breast Cancer

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