Unusual presentation of early lymphogranuloma venereum in an HIV-1 infected patient: effective treatment with 1 g azithromycin

Nieuwenhuis, R F; Ossewaarde, Jacobus M.; Meijden, W I van der; Neumann, H. A. Martino

doi:10.1136/sti.79.6.453

Cited by 76 publications

(52 citation statements)

References 14 publications

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“…In February 2003 the first case of LGV proctitis in Europe was detected in a recently infected HIV-positive bisexual white man who presented with a painful perianal ulcer, bilateral inguinal lymphadenitis and general malaise in Rotterdam, the Netherlands (NL) [26]. Subsequently, a cluster of 13 MSM with LGV serovar L2 was detected through contact tracing [3], most of whom were HIVpositive.…”

Section: Epidemiologymentioning

confidence: 99%

Lymphogranuloma venereum proctocolitis: a silent endemic disease in men who have sex with men in industrialised countries

Martín-Iguacel

Llibre

Nielsen

et al. 2010

Eur J Clin Microbiol Infect Dis

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Lymphogranuloma venereum (LGV) is a sexually transmitted disease (STD) caused by serovars L1-L3 of Chlamydia trachomatis. Rare in the western world prior to 2003, different outbreaks or clusters of LGV have been reported in Europe, North America and Australia among men who have sex with men (MSM) over the past few years. The majority were HIV infected MSM with high-risk sexual behaviour and a high rate of concomitant STD, including hepatitis C. Most of them presented with a proctitis syndrome and only a few with the classical bubonic form. A previously non-described serovar, L2b, has been identified as the main causative agent of the epidemic. A delay in diagnosis has been the rule because of the misleading symptomatology of LGV proctitis, the unfamiliarity of the disease to physicians, and the lack of a routine diagnostic test for LGV serovars. It is crucial to increase the awareness of the disease among physicians for prompt diagnosis and treatment, to avoid complications, and to stop ongoing transmission. It has additional public health implications since LGV may facilitate the transmission and acquisition of HIV and other STD.

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Section: Epidemiologymentioning

confidence: 99%

Lymphogranuloma venereum proctocolitis: a silent endemic disease in men who have sex with men in industrialised countries

Martín-Iguacel

Llibre

Nielsen

et al. 2010

Eur J Clin Microbiol Infect Dis

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“…This tropical sexually transmitted infection is currently responsible for outbreaks of ulcerative proctitis mainly affecting homosexual men (many with HIV infection) in various European countries and the USA. [4][5][6] Uncomplicated lower genital tract chlamydia infections can be cured by a single dose or short course of antibiotics. 7 The term 'chlamydia' is used throughout this report to mean genital C. trachomatis infection caused by strains D-K.…”

Section: Chlamydia and Its Clinical Consequencesmentioning

confidence: 99%

“…A multidisciplinary project, the Chlamydia Screening Studies (ClaSS) project, which used a variety of research methods to investigate these wideranging questions in linked studies, was designed. This report presents the background to the project (this chapter), the overall design and component studies (Chapter 2), detailed methods, results and interpretation for the component studies (Chapters [3][4][5][6][7][8][9][10], and a discussion of the overall results and implications of the component studies (Chapter 11).…”

Section: Recommendations For Researchmentioning

confidence: 99%

Epidemiological, social, diagnostic and economic evaluation of population screening for genital chlamydial infection

Low

McCarthy²,

Macleod³

et al. 2007

Health Technol Assess

133

179

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“…Als effektiv wird auch Azithromycin 1 g als Einmalgabe [9] oder 1 g/Woche über 3 Wochen beschrieben, ist jedoch nicht ausreichend durch Studien belegt [4,15].…”

Section: Therapieunclassified

Lymphogranuloma venereum

et al. 2006

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Lymphogranuloma venereum (LGV) caused by Chlamydia trachomatis serovar L1-3 was formerly a rare sexually transmitted disease in western countries. Recently, an outbreak of LGV and LGV proctitis among men who have sex with men (MSM) was reported from the Netherlands. We report two cases from Dresden, Germany, of white HIV1-infected MSM who presented in November 2004 with genital ulcers along with inguinal lymphadenitis (case 1) and ulcerative proctitis (case 2). The clinical picture and high titers of serum IgG and IgA antibodies pointed to infection with Chlamydia trachomatis. Appropriate specimens were positive for Chlamydia trachomatis with culture and PCR. Subsequent genotyping of the major outer membrane protein (MOMP) by restricted fragment length polymorphism confirmed serovar L2. Treatment with doxycycline for 3-4 weeks was effective. The incidence of LGV is increasing among MSM in Europe. Since most of the reported cases have been HIV1-infected and ulcerative STDs enhance HIV transmission, both health care providers and patients should be more aware of LGV.

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Unusual presentation of early lymphogranuloma venereum in an HIV-1 infected patient: effective treatment with 1 g azithromycin

Cited by 76 publications

References 14 publications

Lymphogranuloma venereum proctocolitis: a silent endemic disease in men who have sex with men in industrialised countries

Lymphogranuloma venereum proctocolitis: a silent endemic disease in men who have sex with men in industrialised countries

Epidemiological, social, diagnostic and economic evaluation of population screening for genital chlamydial infection

Lymphogranuloma venereum

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