Unusual presentation of choriocarcinoma

Balagopal, P.G.; Pandey, Manoj; Chandramohan, K; Somanathan, Thara

doi:10.1186/1477-7819-1-4

Cited by 30 publications

(20 citation statements)

References 2 publications

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“…According to I.A. McNeish et al [9], proper classification of patients (as low risk) did not compromise outcome, but rather prevented undue exposure to potentially carcinogenic chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…However, I.A. McNeish et al [9] have proposed a new scoring system: Charing Cross scoring system (Table 1), which is intended to further reduce the risk of undue exposure to chemotherapy. This new system proposes the use of Methotrexate-Folinic acid regimen for low risk disease (score 0 -8), while EMA/CO (Etoposide, Methotrexate, Actinomycin D, Cyclophosphamide and Oncovin) is reserved for high risk disease (score > 8).…”

Section: Discussionmentioning

confidence: 99%

“…[1] Whereas for those with medium-risk disease, the chemotherapy regimen consisted of MTX as above, plus oral Hydroxyurea 1 g on day 1, oral mercaptopurine 75 mg on the same day as the FA, alternating with courses of either intravenous Etoposide 250 mg/m 2 on days 1 and 3, or courses of intravenous Actinomycin 0.5 mg daily for 5 days. 2 Treatment for high-risk disease was infusional chemotherapy according to the Etoposide, Methotrexate, and dActinomycin (EMA)/Cyclophosphamide and Vincristine (CO) regimen 3 ( Table 2) [9].…”

Section: Discussionmentioning

confidence: 99%

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Uterine choriocarcinoma: A gynaecological masquerader case report and review of the literature

Nnah¹,

Umezurike²,

Akwuruoha³

2013

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Background: Choriocarcinoma is a rare clinical condition, and its diagnosis may be difficult, especially in resource-limited settings. Case Presentation: A 38-year old para 2 woman is with a 4-month history of intractable vaginal bleeding and offensive vaginal discharge, but without antecedent pregnancy. She had previously been managed at various tertiary medical institutions where several pelvic ultrasound scans and even histology of endometrial curette could not clinch the diagnosis. The diagnosis of choriocarcinoma was made by a serial strip-based pregnancy testing, which was still positive at 1:200 dilutions. She was treated with chemotherapy involving Adriamycin, Cyclophosphamide, Methotrexate and Folinic acid. Conclusion: The diagnosis of choriocarcinoma may be difficult especially when it develops ab initio without preceding abortion, molar or term pregnancy. In settings where serum hCG assay may be not available, the simple strip-based pregnancy test in dilution could be helpful in its diagnosis and treatment monitoring.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Uterine choriocarcinoma: A gynaecological masquerader case report and review of the literature

Nnah¹,

Umezurike²,

Akwuruoha³

2013

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“…The incidence of gestational trophoblastic disease (GTD) varies between 1 in 120 pregnancies in some parts of Asia and South America and 1 in 1,200 in the United States [2]. Although choriocarcinoma, a form of GTD, is relatively rare, cases have been found in Africa, Asia and South America, with a majority of them occurring in women aged below 35 [3].…”

Section: Discussionmentioning

confidence: 99%

Peripartum Respiratory Failure with Bilateral Pulmonary Infiltrates on Chest X-Ray

Kwan

Koo

2009

Case Rep Oncol

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Choriocarcinoma is a gestational trophoblastic disease that carries high mortality. As this disease is highly responsive to chemotherapy, early diagnosis could lead to a favorable outcome. We report a case of metastatic pulmonary choriocarcinoma presented with hemoptysis and respiratory failure in a young woman at her third trimester. This report discusses the dilemma in deriving the diagnosis of choriocarcinoma and briefly outlines the current approaches to its treatment. Potentially life-threatening choriocarcinoma should be considered in all unusual chest radiographs of women of childbearing age. Clinicians should be aware of this possibility and proceed with the most appropriate diagnostic procedures.

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“…The favoured sites are the lung (94%), vagina (44%), liver (28%), and brain (28%), followed by the skin, gastrointestinal tract, kidney, breast, and bones [1, 5–7]. However, the isolated involvement of bone marrow is not cited in the literature.…”

Section: Discussionmentioning

confidence: 99%

ecancermedicalscience

Singh

Sardhana

Sharma

et al.

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Gestational trophoblastic diseases (GTD) are a heterogenous group of disorders that arise from trophoblastic epithelium. They can follow molar pregnancy (50%), abortions (25%), normal pregnancy (22.5%), and ectopic pregnancy (2.5%) [Robert JK, Lora HE, Brigitte MR (ed) Blaustein Pathology of the Female Genital Tract 6th edn (Springer) pp. 1101–7]. Occurrence of choriocarcinoma following normal delivery presenting as an isolated bone marrow metastasis is extremely rare, and no case has been cited in the literature, to the best of our knowledge. We are reporting a case of choriocarcinoma that presented with isolated bone marrow metastasis only.

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Unusual presentation of choriocarcinoma

Abstract: Background: Choriocarcinoma is an aggressive neoplasm arising in the body of the uterus. The disease normally spreads to lung and brain.

Cited by 30 publications

References 2 publications

Uterine choriocarcinoma: A gynaecological masquerader case report and review of the literature

Uterine choriocarcinoma: A gynaecological masquerader case report and review of the literature

Peripartum Respiratory Failure with Bilateral Pulmonary Infiltrates on Chest X-Ray

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