Unusual Patterns of Thoracic Metastasis of Urinary Bladder Carcinoma

Hiensch, Robert; Belete, Habtamu; Rashidfarokhi, Mahsan; Galperin, Irene; Shakil, Fouzia; Epelbaum, Oleg

doi:10.4103/jcis.jcis_9_17

Cited by 6 publications

(4 citation statements)

References 47 publications

(57 reference statements)

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“…Because of its rarity, the initial diagnosis of the primary tumor in the present case was urothelial carcinoma. Only a few cases of BC metastasis other than small cell carcinoma to mediastinal lymph nodes have been reported [10][11][12], and, to the best of our knowledge, there is no previous report of isolated mediastinal metastasis from a small cell carcinoma of the bladder. A small cell carcinoma related to BC is known for an aggressive clinical course, with early vascular and muscle invasion, and high propensity for metastasis; thus, the prognosis is poor, with an overall 5-year survival rate ranging from 8 to 25% [2].…”

Section: Discussionmentioning

confidence: 83%

Surgical resection of mediastinal metastasis from small cell carcinoma of bladder: case report

Isono

Kimura

et al. 2022

Gen Thorac Cardiovasc Surg Cases

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Background Isolated mediastinal metastasis from a malignant tumor and small cell carcinoma of the bladder are both very rare. Case presentation A 76-year-old woman who had undergone surgery for bladder cancer twice was referred to our hospital for a right paracardiac mass noted in chest computed tomography findings, and resection of the tumor was performed. Histological analysis of the mediastinal tumor revealed it to be a metastatic small cell carcinoma of the bladder. At 4 months after surgery, multiple metastatic lesions were found in the chest and liver, and chemotherapy for small cell carcinoma was started. Conclusions We present this case of mediastinal metastasis of small cell carcinoma of the bladder, which is very rare, to show the importance of surgical resection of an isolated mediastinal tumor. Such a procedure should be considered, as histological diagnosis of the tumor could be useful for determining therapeutic options.

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Section: Discussionmentioning

confidence: 83%

Surgical resection of mediastinal metastasis from small cell carcinoma of bladder: case report

Isono

Kimura

et al. 2022

Gen Thorac Cardiovasc Surg Cases

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“…Thoracic metastases from UC are frequently noted, predominantly as solid parenchymal lesions, which are characteristic of hematogenous seeding in the lung. Hiensch et al ( 24 ) highlighted several atypical thoracic metastases from UC, including mediastinal lymphadenopathy. Notably, all these cases showed clear evidence of primary tumors.…”

Section: Discussionmentioning

confidence: 99%

Occult urothelial carcinoma with mediastinal metastasis: A case report

Zheng,

Peng,

et al. 2024

Oncol Lett

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Occult urothelial carcinoma (UC), particularly with mediastinal metastases, is an uncommon clinical occurrence. The present study describes the unusual case of a 70-year-old male patient who developed mediastinal metastases from an occult UC. Histological evaluations and immunohistochemical features of the mediastinal tumor were indicative of UC; however, extensive imaging failed to identify the primary urological lesion. The findings suggest that mediastinal metastases from UCs, despite their rarity, should be considered in cases where patients with mediastinal tumors exhibit chest-related symptoms. Prompt pathological examinations are crucial for ascertaining the nature and origin of the tumor. Moreover, individualized treatment should be performed in strict accordance with the established oncology guidelines.

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“…Patterns and anatomic locations of metastatic spread from BCa are generally deemed random and unpredictable. Although certain sites (eg, lung) are more common than others (eg, brain), chronologic timing and lethality implications of site-specific metastases remain largely unknown [18] , [19] . Recent work by Shou et al [20] investigate the prognostic effect of specific combinations of metastases (bone, lung, liver, and brain) on overall survival.…”

Section: Introductionmentioning

confidence: 99%

Prediction of Metastatic Patterns in Bladder Cancer: Spatiotemporal Progression and Development of a Novel, Web-based Platform for Clinical Utility

Mason

Hasnain

Miranda

et al. 2021

European Urology Open Science

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Background Bladder cancer (BCa), the sixth commonest cancer in the USA, is highly lethal when metastatic. Spatial and temporal patterns of patient-specific metastatic spread are deemed random and unpredictable. Whether BCa metastatic patterns can be quantified and predicted more accurately is unknown. Objective To develop a web-based calculator for forecasting metastatic progression in individual BCa patients. Design, setting, and participants We used a prospectively collected longitudinal dataset of 3503 BCa patients who underwent a radical cystectomy following diagnosis and were enrolled continuously. We subdivided patients by their pathologic subgroup stages of organ confined (OC), extravesical (EV), and node positive (N+). We illustrated metastatic pathway progression using color-coded, circular, tree ring diagrams. We created a dynamical, data-visualization, web-based platform that displays temporal, spatial, and Markov modeling figures with predictive capability. Outcome measurements and statistical analysis Patients underwent history and physical examination, serum studies, and liver function tests. Surveillance follow-up included computed tomography scans, chest x-rays, and radiographic evaluation of the reservoir and upper tracts, with bone scans performed only if clinically indicated. Outcomes were measured by time to clinical recurrence and overall or progression-free survival. Results and limitations Metastases developed in 29% of patients ( n = 812; median follow-up 15.3 yr), with 5-yr overall survival of 20.2%, compared with 78.6% in those without metastases ( n = 1983; median follow-up 10.9 yr). The three commonest sites of spread at the time of first progression were bone ( n = 214; 26.4%), pelvis ( n = 194; 23.9%), and lung ( n = 194; 23.9%). The order and frequency of these sites vary when divided by pathologic subgroup stages of OC (lung [ n = 65; 25.1%], urethra [ n = 45; 17.4%], and bone [ n = 29; 11.2%]), EV (pelvis [ n = 63; 33.0%], bone [ n = 45; 23.6%], and lung [ n = 29; 15.2%]), and N+ (bone [ n = 111; 30.7%], retroperitoneum [ n = 70; 19.3%], and pelvis [ n = 60; 16.6%]). Markov chain modeling indicated a higher probability of spread from bladder to bone (15.5%), pelvis (14.7%), and lung (14.2%). Conclusions Our web-based calculator allows real-time analyses in the clinic based on individual patient-specific demographic and cancer data elements. For contrasting subgroups, the models indicated differences in Markov transition probabilities. Spatiotemporal pa...

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Unusual Patterns of Thoracic Metastasis of Urinary Bladder Carcinoma

Cited by 6 publications

References 47 publications

Surgical resection of mediastinal metastasis from small cell carcinoma of bladder: case report

Surgical resection of mediastinal metastasis from small cell carcinoma of bladder: case report

Occult urothelial carcinoma with mediastinal metastasis: A case report

Prediction of Metastatic Patterns in Bladder Cancer: Spatiotemporal Progression and Development of a Novel, Web-based Platform for Clinical Utility

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