Abstract:Pyrimidines have
always received considerable attention because
of their importance in synthesis and elucidation of biochemical
roles, in particular that of vitamin B1. Herein, we describe a reaction
pathway in a Grignard reagent-based synthesis of substituted pyrimidines.
A general synthesis of α-keto-2-methyl-4-amino pyrimidines and
their C6-substituted analogues from 4-amino-5-cyano-2-methylpyrimidine
is reported. The presence of the nitrile substituent in the starting
material also results in an unusual re… Show more
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