Unusual Naturally Occurring Humoral and Cellular Mutated Epitopes of Hepatitis B Virus in a Chronically Infected Argentine Patient with Anti-HBs Antibodies

Cuestas, María Luján; Mathet, Verónica Lidia; Ruiz, Vanesa; Minassian, María Laura; Rivero, Cintia W.; Sala, Andrea; Corach, Daniel; Alessio, Analía; Pozzati, Marcia; Frider, Bernardo; Oubiña, José R.

doi:10.1128/jcm.00057-06

Cited by 19 publications

(21 citation statements)

References 44 publications

(40 reference statements)

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“…The first region contains both a major histocompatibility complex class I (MHC-I)-restricted T-cell epitope and a B-cell epitope, while the second region, at least up to aa 207, displays both MHC-II T helper epitopes and B-cell epitopes. It was also reported that changes within this second region, located immediately downstream of the a determinant, may cause alterations in the structural component of such immunogenic determinant [30,34].…”

Section: Hbsag Mutantsmentioning

confidence: 99%

“…Thus, antibodies targeting this determinant are supposed to protect against re-infection with any of the HBV genotypes [29]. Changes in the conformation which can successively alter the binding of neutralizing antibodies can occur due to amino acid substitutions within the a determinant [30].…”

Section: Hbsagmentioning

confidence: 99%

“…HBsAg-immune-escape mutants may be found both within and without the a determinant [30]. In this connection, it was suggested that areas located upstream and downstream of the MHR may play an important role in neutralization [33].…”

Section: Hbsag Mutantsmentioning

confidence: 99%

“…Some reports from Argentina have recently documented the emergence of S-immune escape mutants in spite of the presence of usually protective anti-HBs antibodies [8,20,21,30,34,56,57] and of cytotoxic T lymphocyte-specific clones [30]. Some of them occurred naturally in HBV-chronically infected patients while others are the result of selected immunological pressures upon vaccination.…”

Section: Current Prevalence Of S-escape Mutantsmentioning

confidence: 99%

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Hepatitis B Virus (HBV) and S-Escape Mutants: From the Beginning until Now

Maria¹

2015

JHVRV

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Despite of the progress made in vaccine and antiviral therapy development, hepatitis B virus (HBV) infection remains a major health care problem. More than 240 million people are chronically infected worldwide showing differences in the severity of liver disease, clinical outcome and response to immune-and antiviraltherapy. Parameters associated with the host immune system (HBV specific Tand/or B-cell repertoires, defective antigen presentation and diminished Th1/ Th2 response ratio) and viral factors such as the HBV genotypes and their evolving variants/mutants, have largely contributed to explaining such differences. The unique genomic structure and replication cycle of HBV provide much opportunity for mutations to occur in any of its genes undergoing selection pressures, such as those associated with the host immune system, the hepatitis B vaccine and/ or hepatitis B immune globulin and the antiviral therapy with nucleos(t)ide analogues. Firstly, this review describes the current prevalence of S-escape mutants worldwide. Secondly, the clinical implications of such surface gene variants and the impact of universal hepatitis B vaccination on HBV mutations and genotypes are discussed. Finally, the fact that the immune escape process also extends well beyond HBV is addressed.

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Section: Hbsag Mutantsmentioning

confidence: 99%

Section: Hbsagmentioning

confidence: 99%

Section: Hbsag Mutantsmentioning

confidence: 99%

Section: Current Prevalence Of S-escape Mutantsmentioning

confidence: 99%

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Hepatitis B Virus (HBV) and S-Escape Mutants: From the Beginning until Now

Maria¹

2015

JHVRV

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“…Changes in the conformation which can successively lead to failure of binding of neutralizing antibodies may develop due to amino acid substitutions within the" a" determinant [30]. Mutations in HBV occur due to low fidelity of polymerase, high replication rate and overlapping reading frames.…”

Section: Hepatitis B Surface Antigen (Hbsag)mentioning

confidence: 99%

Hepatitis B Virus_Surface Gene Mutations and Their Clinical Implications

Hamadalnil¹,

Bakheit²

2017

SJMS

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PreS deletion mutations of hepatitis B virus in chronically infected patients with simultaneous seropositivity for hepatitis‐B surface antigen and anti‐HBS antibodies

Huang

Qin

Zhang

et al. 2009

Journal of Medical Virology

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Hepatitis B surface antigen (HBsAg) and anti-HBs antibodies (anti-HBs) may coexist in certain chronic hepatitis B (CHB) patients. This study was designed to further explore the relationship between this coexistence and hepatitis B Virus (HBV) preS deletions. Sera of 28 patients carrying both HBsAg and anti-HBs (Group I) and those of another 28 HBsAg positive but anti-HBs negative patients (Group II) were collected from CHB patients. Direct sequencing of polymerase chain reaction products or sequencing of clones was applied to both groups to determine sequences of HBV preS and S genes. Genotyping of the S gene indicated that all sampled HBVs were either Genosubtype Ba or Genosubtype Ce. Seven samples in Group I harbored HBV preS deletion mutations. Three of the seven samples showed large deletion mutations in 3' terminus of preS1 and co-existence of the mutant type and the full-length wild type, and the remaining four samples showed deletion mutations in 5' terminus of preS2. All mutant strains were found to be genosubtype Ce. Only two samples in Group I showed G145R/A mutation. Only one sample in Group II contained preS deletion mutation. It is therefore concluded that HBV preS deletion mutations are likely to be related to the coexistence of HBsAg and anti-HBs in CHB patients (P-value = 0.024). Some immune reactions may select for the preS deletion in CHB patients with anti-HBs, the possible marker for immune selection.

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Unusual Naturally Occurring Humoral and Cellular Mutated Epitopes of Hepatitis B Virus in a Chronically Infected Argentine Patient with Anti-HBs Antibodies

Abstract: Serum hepatitis B virus (HBV)DNA

Cited by 19 publications

References 44 publications

Hepatitis B Virus (HBV) and S-Escape Mutants: From the Beginning until Now

Hepatitis B Virus (HBV) and S-Escape Mutants: From the Beginning until Now

Hepatitis B Virus_Surface Gene Mutations and Their Clinical Implications

PreS deletion mutations of hepatitis B virus in chronically infected patients with simultaneous seropositivity for hepatitis‐B surface antigen and anti‐HBS antibodies

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