Unusual multiple metastases from malignant pleomorphic adenoma of the parotid gland

Cherian, Thomas; Stolzmann, Paul; Abraham, Elizabeth; Ahmed, Ijaz; Jayakumar, Karthikesh; Sivaramakrishnan, P.

doi:10.1017/s0022215100120444

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…Including our cases, to the best of our knowledge, there have been only 44 reported parotid neoplasm cases with cutaneous metastasis in the English literature (Table 1). 9–48 In this review, most patients were men (66%), with a mean age at diagnosis or appearance of parotid neoplasm of 49.2 years, which is similar to parotid carcinomas epidemiology. 1…”

Section: Discussionmentioning

confidence: 52%

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Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

Puerto

Jaque

González-Bombardiere³

et al. 2021

The American Journal of Dermatopathology

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Cutaneous metastases from parotid tumors are uncommon and imply a poor prognosis. In this article, we report 2 new cutaneous metastasis cases from 2 different parotid malignancies and 42 additional cases from a literature review. Clinical manifestations, localization, and outcomes of skin metastasis from parotid tumors are described. Although infrequent, parotid neoplasms may develop skin metastasis many years after the initial diagnosis, mostly in the head and neck region. Therefore, long-term follow-up and periodic skin examination of these patients is mandatory. Dermatologists and surgeons must have a high index of suspicion when evaluating any skin lesion arising on these patients because cutaneous metastasis from parotid neoplasms generally implies a poor prognosis.

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Section: Discussionmentioning

confidence: 52%

“…According to a PubMed and Ovid database search, only 42 cases of cutaneous metastases from parotid neoplasms have been reported since 1956 (search date January 1, 1956, to July 31, 2020). 9–48 We describe 2 cases of parotid malignancies with cutaneous metastasis and a literature review of cutaneous metastasis from parotid tumors.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

Puerto

Jaque

González-Bombardiere³

et al. 2021

The American Journal of Dermatopathology

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“…Additional cases of carcinosarcoma (Tortoledo et al, 1984;Talmi et al, 1990;Cherian et al, 1992), metastasizing mixed tumor (Freeman et al, 1990;Sim et al, 1990;Pitman et al, 1992), and carcinoma in mixed tumor (Tortoledo et al, 1984) were further reported.The frequency of carcinosarcoma, and carcinoma in mixed tumor, was reported to be 0.2% (Tortoledo et al, 1984), and 2.1% (Moberger and Eneroth, 1968), respectively. Moberger and Eneroth (l968) further reported that distant metastases were present in 28.1% of all carcinoma in mixed tumor cases, but that no pleomorphic structures were demonstrable in the metastatic lesions.They further pointed out the difficulty of evaluating cellular atypia as a marker of malignancy in pleomorphic adenoma, and also that the lack of sharp delimitation and absence of a capsule may give a false impression of infiltration.…”

Section: Detection Of Procancer Clones In Otorhinolaryngeal Borderlinmentioning

confidence: 96%

The DNA-instability test as a specific marker of malignancy and its application to detect cancer clones in borderline malignancy

Fukuda¹,

Sun²

2009

Eur J Histochem

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Recent progress in cytogenetic and biochemical mutator assay technologies has enabled us to detect single gene alterations and gross chromosomal rearrangements, and it became clear that all cancer cells are genetically unstable. In order to detect the genome-wide instability of cancer cells, a new simple method, the DNA-instability test, was developed. The methods to detect genomic instability so far reported have only demonstrated the presence of qualitative and quantitative alterations in certain specific genomic loci. In contrast to these commonly used methods to reveal the genomic instability at certain specific DNA regions, the newly introduced DNA-instability test revealed the presence of physical DNA-instability in the entire DNA molecule of a cancer cell nucleus as revealed by increased liability to denature upon HCl hydrolysis or formamide exposure. When this test was applied to borderline malignancies, cancer clones were detected in all cases at an early-stage of cancer progression. We proposed a new concept of "procancer" clones to define those cancer clones with "functional atypia" showing positivities for various cancer markers, as well as DNA-instability testing, but showing no remarkable ordinary "morphological atypia" which is commonly used as the basis of histopathological diagnosis of malignancy.

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Metastases from Tumors of the Head and Neck

2002

TxNxM1

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Unusual multiple metastases from malignant pleomorphic adenoma of the parotid gland

Cited by 6 publications

References 6 publications

Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

The DNA-instability test as a specific marker of malignancy and its application to detect cancer clones in borderline malignancy

Metastases from Tumors of the Head and Neck

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