Unusual metastasis of gastrointestinal stromal tumor misdiagnosed as anaplastic thyroid carcinoma

Peparini, Nadia; Fm, Di Matteo; Maturo, A; Marzullo, A; Campana, Francesco

doi:10.1016/j.ijsu.2006.05.008

Cited by 12 publications

(18 citation statements)

References 8 publications

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Section: Discussionmentioning

confidence: 99%

“…On the basis of histologic data, cytologic case reports, and small FNAB series, there is an SNTG subset that exhibits morphologic features overlapping with those of primary thyroid carcinomas, including PTC, follicular thyroid carcinoma, medullary thyroid carcinoma, PDTC, and UTC, and, thus, constitutes a potential pitfall in cytologic evaluation. 24,26,32,[50][51][52][53][54][55][56] Clearly, a major challenge in the diagnosis of SNTG is related to the wide variety of histologic types and primary tumor origins that can be encountered. In addition, the diagnosis of SNTG by FNAB can be made more difficult by a lack of clinical history indicating an extrathyroid cancer or by a long lag time between primary diagnosis and the development of an SNTG.…”

Section: Accuracy Of Fnab and Differential Diagnosis Of Sntgmentioning

confidence: 99%

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Fine‐needle aspiration biopsy of secondary neoplasms of the thyroid gland: A multi‐institutional study of 62 cases

Pusztaszeri

Wang

Cibas

et al. 2014

Cancer Cytopathology

100

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BACKGROUND: Secondary neoplasms of the thyroid gland (SNTGs) are uncommon, and it is important to recognize them in thyroid fine-needle aspiration biopsy (FNAB). METHODS: The authors report a cohort of 62 SNTGs from 7 institutions in the United States and Europe. Patients were identified retrospectively by searching through medical records of the respective institutions. All initial diagnoses were rendered by FNAB. RESULTS: SNTGs represented 0.16% of all thyroid FNABs and were more frequent among women (ratio of women to men, 1.2:1.0). The mean patient age was of 59 years (range, 7-84 years), the mean tumor size was 3 cm (range, 0.9-7 cm), and the mean interval from diagnosis of the primary tumor was 45 months (range, 0-156 months). Eighty-seven percent of SNTGs were diagnosed as malignant by FNAB, and there was a specific SNTG diagnosis in 93% of patients. Immunocytochemistry and flow cytometry, which were used in 30% of patients, were useful ancillary studies. Adenocarcinomas (n 5 23; 37%) and squamous cell carcinomas (SCCs) (n 5 22; 35.5%) represented the majority of SNTGs, followed by lymphoma (n 5 5; 8%), melanoma (n 5 5; 8%), adenoid cystic carcinoma (n 5 3; 5%), and various sarcomas (n 5 3; 5%). Adenocarcinomas originated from the kidney (n 5 9; 39%), lung (n 5 6; 26%), breast (n 5 5; 22%), and colon (n 5 3; 13%). SCCs originated mostly from the head and neck (n 5 13; 59%), followed by lung (n 5 3; 13%), esophagus (n 5 3; 14%), and unknown primary sites (n 5 3; 14%). CONCLUSIONS:Adenocarcinomas from the kidney, lung, breast, and colon along with SCCs represent the majority of SNTGs. The current results indicate that FNAB is a sensitive and accurate method for diagnosing SNTG; however, diagnostic difficulties can occur. Knowledge of clinical history and the judicious application of ancillary studies can increase the sensitivity and accuracy of FNAB for detecting SNTGs. Cancer (Cancer Cytopathol) 2015;123:19-29. V C 2014 American Cancer Society.KEY WORDS: thyroid; secondary neoplasm; metastasis; renal cell carcinoma; squamous cell carcinoma; adenocarcinoma; lymphoma; adenoid cystic carcinoma; fine-needle aspiration; cytology. INTRODUCTIONSecondary neoplasms of the thyroid gland (SNTGs), representing either metastases or direct extension of tumors from adjacent anatomic structures, are uncommon. Their reported incidence varies substantially, however, ranging from 0.1% to 3% in clinical series. 1-15 They have been reported as incidental findings in autopsy studies [16][17][18] with a frequency of 4.4% to 24% in patients with a known primary cancer or widespread Original Article malignancy in which clinically occult thyroid micrometastases may be detected. 4,[19][20][21][22] In the United States and Europe, the most commonly reported primary tumor resulting in symptomatic SNTG is renal cell carcinoma (RCC), closely followed by carcinomas of the breast, lung, and colon. 5,23-25 Secondary lymphoma, melanoma, sarcoma, and head and neck squamous cell carcinoma (SCC) also account for a significant proportion of SNT...

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Section: Discussionmentioning

confidence: 99%

Section: Accuracy Of Fnab and Differential Diagnosis Of Sntgmentioning

confidence: 99%

Fine‐needle aspiration biopsy of secondary neoplasms of the thyroid gland: A multi‐institutional study of 62 cases

Pusztaszeri

Wang

Cibas

et al. 2014

Cancer Cytopathology

100

View full text Add to dashboard Cite

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“…Nevertheless, even sophisticated techniques cannot reliably differentiate between primary thyroid lesions and metastases 28,54. Fine needle aspiration cytology (FNAC) can often be of assistance 55,56.…”

Section: Preoperative Investigationmentioning

confidence: 99%

“…There limitations of cytology are acknowledged 29,56,60. Poorly differentiated tumors such as aggressive anaplastic thyroid cancers can be difficult to differentiate from-high grade metastases 54,58,61,62. In addition, neck hematoma after needle biopsy of RCC has anecdotally been seen and should raise concerns for performing core biopsies of lesions suspicious for RCC.…”

Section: Preoperative Investigationmentioning

confidence: 99%

Metastasis to the Thyroid Gland: A Critical Review

et al. 2016

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BackgroundMetastasis to the thyroid gland from nonthyroid sites is an uncommon clinical presentation in surgical practice. The aim of this review was to assess its incidence management and outcomes.MethodsA literature review was performed to identify reports of metastases to the thyroid gland. Both clinical and autopsy series were included.ResultsMetastases to the gland may be discovered at the time of diagnosis of the primary tumor, after preoperative investigation of a neck mass, or on histologic examination of a thyroidectomy specimen. The most common primary tumors in autopsy studies are from the lung. In clinical series, renal cell carcinoma is most common. For patients with widespread metastases in the setting of an aggressive malignancy, surgery is rarely indicated. However, when patients present with an isolated metastasis diagnosed during follow-up of indolent disease, surgery may achieve control of the central neck and even long-term cure. Other prognosticators include features of the primary tumor, time interval between initial diagnosis and metastasis, and extrathyroid extent of disease.ConclusionsIn patients with thyroid metastases, communication among clinicians treating the thyroid and the index primary tumor is essential. The setting is complex, and decisions must be made considering the features of the primary tumor, overall burden of metastases, and comorbidities. Careful balancing of these factors influences individualized approaches.

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“…(2012) провели обзор англо-язычной литературы с 2000 по 2010 г. в отношении метастазов злокачественных опухолей в щитовидную железу. Ими был найден 131 источник, где сообщалось в общей сложности о 374 случаях метастатического поражения щитовидной железы [21,[23][24][25][26][27][28], причем у женщин поражений было больше, чем у мужчин, в 1,4 раза, а медиана возраста составила 60 лет [21]. М.K.…”

Section: Introductionunclassified

Metastases of kidney cancer into the thyroid gland (сlinical observation)

Огнерубов¹,

Барсуков²,

Chang³

et al. 2017

Opuholi golovy šei

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Key words: thyroid gland, metastases, renal cell carcinomaВведение Рак почки составляет 3,9 % от общего числа онко-логической патологии [1] и 90 % всех злокачественных новообразований почки [2]. Пик заболеваемости при-ходится на 50-60 лет. У мужчин рак почки развивается чаще, чем у женщин (соответственно 4,7 и 3,3 %, или 7-е и 9-е места [1,3]).Метастатическое поражение щитовидной железы является редким случаем, хотя эта железа после надпо-чечников наиболее васкуляризирована [4][5][6][7][8]. В лите-ратуре этот факт объясняют, ссылаясь на гипотезу R. Willis (1931), согласно которой быстрый ток крови через щитовидную железу препятствует прилипанию опухолевых клеток и, кроме того, высокое содержание кислорода и йода тормозит развитие злокачественных клеток [9].Так, H. Chen и соавт. (1999) при ретроспективном исследовании выявили за 8 лет только 10 случаев ме-тастатического поражения щитовидной железы в 1 уч-реждении [10]. K. Kobayashi и соавт. (2015) 15 лет на-блюдали 10 пациентов с метастатическим раком щитовидной железы при почечно-клеточном раке [11]. В клинике Мейо за период в 55 лет выявлено 14 паци-ентов с аналогичной патологией [12].О метастатическом поражении щитовидной желе-зы сообщается в 1,4-3 % случаев среди всех операций на этом органе [13][14][15][16][17][18]. Причем среди всех злокаче-ственных новообразований чаще всего метастазируют опухоли почки (48,1 %), колоректальный рак (10,4 %), рак легких (8,3 %), рак молочной железы (7,8 %), ме-ланома (4 %) и саркома (4 %) [17,[19][20][21]. Но по ре-зультатам вскрытий частота метастазирования коле-

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Unusual metastasis of gastrointestinal stromal tumor misdiagnosed as anaplastic thyroid carcinoma

Abstract: [No abstract available

Cited by 12 publications

References 8 publications

Fine‐needle aspiration biopsy of secondary neoplasms of the thyroid gland: A multi‐institutional study of 62 cases

Fine‐needle aspiration biopsy of secondary neoplasms of the thyroid gland: A multi‐institutional study of 62 cases

Metastasis to the Thyroid Gland: A Critical Review

Metastases of kidney cancer into the thyroid gland (сlinical observation)

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