Unusual Melanocytic Nevi of the Conjunctiva

Zuckerman, Bernard D.; Berlin, A. Jan; Odell, Peter R.; MacRae, Douglas; Tuthill, Ralph J.

doi:10.1016/s0002-9394(14)74991-8

Cited by 35 publications

(9 citation statements)

References 30 publications

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“…Three individual cases have been reported in the conjunctiva, seeming to emphasize the infrequency of combined nevi in this site. 1,24,25 Crawford et al, 26 however, found that 33% of 85 conjunctival nevi removed over a 10-year period were allegedly combined nevi. This is a much higher incidence than we have noticed in our practices.…”

Section: Commentsmentioning

confidence: 99%

Recurrent Blue Nevus of the Corneoscleral Limbus

Nguyen¹,

Bhat²,

Fay³

2010

Cornea

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Section: Commentsmentioning

confidence: 99%

Recurrent Blue Nevus of the Corneoscleral Limbus

Nguyen¹,

Bhat²,

Fay³

2010

Cornea

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“…These cases were described collectively by Albert et al (1985), who presented a pedigree with primary malignant melanomas of the choroid and skin where the proband had a choroidal melanoma but no cutaneous melanocytic lesions, whereas his son had a cutaneous malignant melanoma but no ocular manifestation and his grandchildren atypical melanocytic lesions of the skin clinically. Occurrence of an intraocular malignant melanoma and a malignant skin melanoma as double primaries was reported by Bellet et al (1980), Abramson et al (1980) and Oosterhuis et al (1982), whereas Jakobiec et al (1985) reported a melanoma of the conjunctiva in a patient with the dysplastic naevus syndrome. Occurrence of a choroidal melanoma in the dysplastic naevus syndrome without a malignant skin manifestation as in the present case has not to our knowledge been previously reported.…”

Section: Discussionmentioning

confidence: 92%

Malignant melanoma of the choroid in an infant with the dysplastic naevus syndrome

Jensen

Movin

Müller

1987

Acta Ophthalmologica

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A 7-month-old Algerian boy with numerous skin naevi from birth was found to have a malignant melanoma of the choroid, giving symptoms from the age of 3 months. The ocular and cutaneous tumours were shown to be melanocytic by a battery of histochemical tests and by electron microscopy. The rarity of the case is discussed on basis of the literature, and it is concluded that the case is unique because of the early age at which both the ocular tumour and the dysplastic naevus syndrome occurred.

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“…They can be solitary but more commonly present as combined lesions partnering with conventional conjunctival naevi [14]. Most are of “common” type, but “cellular” [15] and “epithelioid” variants [16] have been published, including 1 example that was multifocal [17]. One report documented malignant transformation in a cellular blue naevus that mimicked primary acquired melanosis [18].…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Blue Naevus in an Anophthalmic Socket

2017

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Purpose of the Study: To describe an unusual brown pigmented lesion of the conjunctiva in an anophthalmic socket in a 16-year-old male. Procedures: A 16-year-old male patient presented with socket irritation whilst wearing an artificial eye due to meibomian gland dysfunction. An area of flat, subepithelial, dark brown pigmentation with irregular and indistinct borders on the bulbar conjunctiva of the anophthalmic socket was seen. The patient believed it had been present for at least 2 years. His past ocular history was of childhood trauma to the right eye at the age of 9 years, and he underwent primary enucleation and hydroxyapatite orbital implant insertion at that time. Unfortunately, the implant extruded and was removed a year later. Results: An incisional biopsy of the pigmented lesion showed a conjunctival, subepithelial bland spindle cell melanocytic lesion, with uniform-sized and -shaped melanosomes. Immunohistochemistry showed the cells to express Melan A and HMB45 and they were negative for CD68 and pan-cytokeratins. The features were of a common blue naevus. Conclusion: This is the first documentation of a post-enucleation conjunctival naevus in an anophthalmic socket. We propose a pathogenesis and suggest surveillance as there is a risk of transformation to melanoma.

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Unusual Melanocytic Nevi of the Conjunctiva

Cited by 35 publications

References 30 publications

Recurrent Blue Nevus of the Corneoscleral Limbus

Recurrent Blue Nevus of the Corneoscleral Limbus

Malignant melanoma of the choroid in an infant with the dysplastic naevus syndrome

Conjunctival Blue Naevus in an Anophthalmic Socket

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