Unusual kinetics of white cell clearance in transfused mice

Goodarzi, Mark O.; Lee, T. ‐H.; Pallavicini, M. G.; Donegan, Elizabeth; Busch, MP

doi:10.1046/j.1537-2995.1995.35295125737.x

Cited by 27 publications

(13 citation statements)

References 19 publications

(2 reference statements)

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“…The infusion of foreign antigens in transfused blood products induces immune suppression, anergy and clonal deletion in studies in experimental animals [26], which may predispose already immunosuppressed cancer patients to tumor cell spread and facilitate tumor growth and reduced survival. However, most studies that have evaluated proposed mechanisms have been performed in rodents, and these findings may not be applicable to the human immune system [27]. Other possible mechanisms that have been postulated to explain the noted association between PBT and survival include the increased incidence of postoperative infection and blood type incompatibility [28].…”

Section: Discussionmentioning

confidence: 99%

Perioperative Blood Transfusion Promotes Worse Outcomes of Bladder Cancer after Radical Cystectomy: A Systematic Review and Meta-Analysis

et al. 2015

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BackgroundMultiple studies have investigated the effect of perioperative blood transfusion (PBT) for patients with radical cystectomy (RC), but the results have been inconsistent. We conducted a systematic review and meta-analysis to investigate the relationship between PBT and the clinical outcomes of RC patients.MethodsWe searched MEDLINE, EMBASE, the Cochrane library and BIOSIS previews to identify relevant literature for studies that focused on the relationship of PBT and outcomes of patients undergoing RC. A fixed or random effects model was used in this meta-analysis to calculate the pooled hazard ratio (HR) with 95% confidence intervals (CIs).ResultsA total of 7080 patients in 6 studies matched the selection criteria. Aggregation of the data suggested that PBT in patients who underwent RC correlated with increased all-cause mortality, cancer-specific mortality and cancer recurrence. The combined HRs were 1.19 (n = 6 studies, 95% CI: 1.11–1.27, Z = 4.71, P<0.00001), 1.17 (n = 4 studies, 95% CI: 1.06–1.30, Z = 3.06, P = 0.002), 1.14 (n = 3 studies, 95% CI: 1.03–1.27, Z = 2.50, P = 0.01), respectively. The all-cause mortality associated with PBT did not vary by the characteristics of the study, including number of study participants, follow-up period and the median blood transfusion ratio of the study.ConclusionOur data showed that PBT significantly increased the risks of all-cause mortality, cancer-specific mortality and cancer recurrence in patients undergoing RC for bladder cancer.

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Section: Discussionmentioning

confidence: 99%

Perioperative Blood Transfusion Promotes Worse Outcomes of Bladder Cancer after Radical Cystectomy: A Systematic Review and Meta-Analysis

et al. 2015

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“…However, most studies evaluating proposed mechanisms have been done in rodents, and these findings may not be applicable to the human immune system. 44 Caution should be exercised, therefore, when findings from experimental animals are extrapolated to humans. Moreover, different biologic mechanisms may be involved in each reported clinical manifestation of TRIM, [1][2][3][4][5][6][7][8][9][10] and the clinical evidence supporting each of the aforementioned hypotheses [1][2][3][4][5][6][7][8][9][10] should be examined on its own merits.…”

mentioning

confidence: 99%

Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction?

Vamvakas

Blajchman

2001

Blood

386

272

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“…This clearly makes it the marker of choice for studies in the mouse (or in any species in which the sex-determining gene has been sequenced) because cells of male donors can be injected into female recipients that are totally congenic (except for sry and other sex-specific genes but these are probably not expressed in the adult). This approach has been successfully applied to follow the fate of transfused leukocytes (17). Thus, there is virtually no concern with respect to immune responses.…”

Section: Resultsmentioning

confidence: 99%

A new approach to determining the rates of recruitment of circulating leukocytes into tissues: Application to the measurement of leukocyte recruitment into atherosclerotic lesions

Steinberg

Khoo

Glass

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

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Recruitment of circulating monocytes into the artery wall is an important feature of early atherogenesis. In vitro studies have identified a number of adhesion molecules and chemokines that may control this process but very little work has been done to evaluate their relative importance in vivo, in part because there have been no methods available of sufficient sensitivity and reliability. This paper proposes a new approach in which advantage is taken of naturally occurring or transgenically induced mutations to ''mark'' donor cells and to follow their fate in recipient animals using highly sensitive PCR methods. The feasibility of the approach is demonstrated by preliminary studies of monocyte recruitment into atherosclerotic lesions. However, the method should in principle be applicable to the study of any of the circulating leukocytes and their rate of entry into any tissue or tissues of interest.

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Unusual kinetics of white cell clearance in transfused mice

Abstract: These results contrast with the rapid clearance of donor WBCs observed in humans and dogs. The immunologic basis for this discrepancy remains unclear. Caution should be exercised in any extrapolation to humans of conclusions drawn from results in transfused mice.

Cited by 27 publications

References 19 publications

Perioperative Blood Transfusion Promotes Worse Outcomes of Bladder Cancer after Radical Cystectomy: A Systematic Review and Meta-Analysis

Perioperative Blood Transfusion Promotes Worse Outcomes of Bladder Cancer after Radical Cystectomy: A Systematic Review and Meta-Analysis

Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction?

A new approach to determining the rates of recruitment of circulating leukocytes into tissues: Application to the measurement of leukocyte recruitment into atherosclerotic lesions

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