Unusual intrauterine objects: potential pitfalls in ultrasonographic identification.

Harnsberger, H R; Lee, T G; Mukuno, D H; Melendez, Mar

doi:10.7863/jum.1983.2.4.169

Cited by 5 publications

(3 citation statements)

References 1 publication

(2 reference statements)

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“…While these health risks are well-researched with regard to food safety and regulation [ 201 ], it is concerning that many LAB are commonly used as probiotics. Indeed, another study has raised concern that some Lactobacillus rhamnosus strains often used in probiotics may produce biogenic amines [ 129 ].…”

Section: The Trace Aminergic Systemmentioning

confidence: 99%

“…In line with this, significant gender differences were reported for trace amine levels [ 126 ]. Furthermore—and specifically relevant to the review topic and IBS—trace amine synthesis has been reported in human neurons, where it is thought to modulate neuronal signalling [ 17 , 148 , 177 ], and high levels of trace amines have been found in specific foods, as well as bacterial secretomes [ 13 , 129 , 153 , 201 ]. Taken together, it is therefore possible that the trace aminergic system may be an additional level of control/maladaptation in IBS that has been largely overlooked until now.…”

Section: Introductionmentioning

confidence: 99%

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The trace aminergic system: a gender-sensitive therapeutic target for IBS?

Pretorius

Smith

2020

J Biomed Sci

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Due to a lack of specific or sensitive biomarkers, drug discovery advances have been limited for individuals suffering from irritable bowel syndrome (IBS). While current therapies provide symptomatic relief, inflammation itself is relatively neglected, despite the presence of chronic immune activation and innate immune system dysfunction. Moreover, considering the microgenderome concept, gender is a significant aetiological risk factor. We believe that we have pinpointed a “missing link” that connects gender, dysbiosis, diet, and inflammation in the context of IBS, which may be manipulated as therapeutic target. The trace aminergic system is conveniently positioned at the interface of the gut microbiome, dietary nutrients and by-products, and mucosal immunity. Almost all leukocyte populations express trace amine associated receptors and significant amounts of trace amines originate from both food and the gut microbiota. Additionally, although IBS-specific data are sparse, existing data supports an interpretation in favour of a gender dependence in trace aminergic signalling. As such, trace aminergic signalling may be altered by fluctuations of especially female reproductive hormones. Utilizing a multidisciplinary approach, this review discusses potential mechanisms of actions, which include hyperreactivity of the immune system and aberrant serotonin signalling, and links outcomes to the symptomology clinically prevalent in IBS. Taken together, it is feasible that the additional level of regulation by the trace aminergic system in IBS has been overlooked, until now. As such, we suggest that components of the trace aminergic system be considered targets for future therapeutic action, with the specific focus of reducing oxidative stress and inflammation.

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Section: The Trace Aminergic Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The trace aminergic system: a gender-sensitive therapeutic target for IBS?

Pretorius

Smith

2020

J Biomed Sci

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“…In teressant ist aber, dass es auch ohne vorangehenden Abort oder Entzündung zu einer Endometriumossifikation kommen kann [8], Diagnostisch stehen verschiedene Mittel zur Verfü gung. Bereits im Ultraschall sind die Befunde recht ein drücklich, wenn auch nicht charakteristisch [9,10]. Ra diologisch sind Ossifikationen sichtbar, wenn zum Bei spiel anlässlich der Hysterosalpingographie eine Auf nahme vor Applikation des Kontrastmittels gemacht wird.…”

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