Unusual initial manifestation of choroidal melanoma in a 46-year-old adult with rapid growth over 9 months

Furashova, Olga; Engelmann, Katrin; Joussen, Antonia M.; Riechardt, Aline I.

doi:10.1016/j.ajoc.2022.101518

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…A recent case report hinting that MAP organisms may be getting to the eye from the surface of the face describes an individual living on an animal farm (of "sharps and pigeons", not dairy cattle) who developed a UvM in his left eye several years after "light blunt trauma" to that eye (120). Nontuberculous mycobacterial ocular infection is associated with surgery of and biomaterials in the cornea and sclera (121), but there are no other reports of UvM associated with trauma to the affected eye.…”

Section: Possible Explanations For the Racial Difference In Patients ...mentioning

confidence: 99%

The evidence for Mycobacterium avium subspecies paratuberculosis (MAP) as a cause of nonsolar uveal melanoma: a narrative review

Pierce¹,

Jindal²,

Choi³

et al. 2023

Transl Cancer Res

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Background and Objective: Animal microorganisms have been proposed as a cause of human cancers associated with farming, agricultural occupation or residence, and related downstream exposures. Several studies have described uveal melanoma (UvM) as a farming-associated cancer. A possible suspect is the animal microorganism Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of paratuberculosis in dairy cows. This microbe is transmitted to humans through various means, including contact with animal faeces, contaminated dust and soil, organic fertilizers, and as workers in slaughterhouses/ animal processing facilities. The objective of the current manuscript was to examine the putative association between Mycobacterium avium sub-species paratuberculosis and non-solar UvM.Methods: Online data sources (PubMed, Scopus, Cochrane Library, and Google) published in English between 1980 to present were searched for key words pertaining to MAP exposure, farming-related occupations and activities, and locations with or in the vicinity of dairy cattle.

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Section: Possible Explanations For the Racial Difference In Patients ...mentioning

confidence: 99%

The evidence for Mycobacterium avium subspecies paratuberculosis (MAP) as a cause of nonsolar uveal melanoma: a narrative review

Pierce¹,

Jindal²,

Choi³

et al. 2023

Transl Cancer Res

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Subretinal Exudation: The First Presentation of Untreated Choroidal Melanomas

Diafas,

Williams,

Ajanaku

et al. 2024

Ocul Oncol Pathol

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Introduction: This case series aims to present the unusual clinical manifestation of subretinal exudation in patients diagnosed with untreated choroidal melanoma. A total of 886 patients were diagnosed and treated for primary choroidal melanoma between November 2017 and June 2023 at St. Paul's Eye Unit, Royal Liverpool University Hospital, UK. The fundus photographs were screened for lipid exudates by two independent clinical experts. The patients’ demographics, clinical manifestations and imaging features were analysed, whereas the location of exudation was documented with fundus photographs and optical coherence tomography (OCT). The histopathological and genetic results were also analysed in cases with tumour biopsy available. Case Presentations: Eight cases with subretinal exudates were identified (n=8/886, 0.90%). No gender predilection was noticed (male/female 1:1), whereas the mean age was 51 years (range 39-79). Four patients were asymptomatic at presentation, two patients reported reduced visual acuity, and two patients presented with photopsia. OCT scans revealed the presence of subretinal fluid and subretinal exudates, while the ultrasound showed medium or low internal reflectivity in 7 out of 8 cases. The biopsy analysis was available in 4 cases, all showing low-risk spindle cell choroidal melanoma with disomy 3. Conclusion: Lipid exudates are an atypical fundoscopic finding in patients with untreated choroidal melanoma. The subretinal location could differentiate them from other retinal vascular conditions and facilitate early diagnosis and intervention. Interestingly, all cases tested cytogenetically were of low metastatic risk; these exudates may, therefore, be a positive clinical prognostic sign.

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Unusual initial manifestation of choroidal melanoma in a 46-year-old adult with rapid growth over 9 months

Cited by 2 publications

References 8 publications

The evidence for Mycobacterium avium subspecies paratuberculosis (MAP) as a cause of nonsolar uveal melanoma: a narrative review

The evidence for Mycobacterium avium subspecies paratuberculosis (MAP) as a cause of nonsolar uveal melanoma: a narrative review

Subretinal Exudation: The First Presentation of Untreated Choroidal Melanomas

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