Unusual histopathological features of cutaneous leishmaniasis identified by polymerase chain reaction specific for <i>Leishmania</i>
 on paraffin-embedded skin biopsies

Böer, Almut; Blödorn‐Schlicht, Norbert; Wiebels, D.; Steinkraus, Volker; Falk, Thomas

doi:10.1111/j.1365-2133.2006.07365.x

Cited by 61 publications

(64 citation statements)

References 10 publications

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“…from a significant number of both single and multiple atypical nodular skin lesions. [1416] From histological point of view, these granulomas, considered “naked” or “sarcoidal granuloma”, are different from the classic tuberculoid granulomas observed in lupus vulgaris and chronic lupoid leishmaniasis, and normally would not be classified as granulomas caused by a living agent. Therefore, organism is either difficult to trace in those chronic lesions or is altogether absent.…”

Section: Discussionmentioning

confidence: 99%

Comorbidity of Leishmania major with cutaneous sarcoidosis

et al. 2014

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Background:leishmaniasis infection might manifest as sarcoidosis; on the other hand, some evidences propose an association between sarcoidosis and leishmaniasis. Most of the times, it is impossible to discriminate idiopathic sarcoidosis from leishmaniasis by conventional histopathologic exam.Aim:We performed a cross-sectional study to examine the association of sarcoidosis with leishmaniasis in histopathologically diagnosed sarcoidal granuloma biopsy samples by polymerase chain reaction (PCR).Materials and Methods:We examined paraffin-embedded skin biopsy samples obtained from patients with clinical and histopathological diagnosis as naked sarcoidal granuloma, referred to Skin Research Center of Shaheed Beheshti Medical University from January 2001 to March 2010, in order to isolate Leishmania parasite. The samples were reassessed by an independent dermatopathologist. DNA extracted from all specimens was analyzed by the commercially available PCR kits (DNPTM Kit, CinnaGen, Tehran, Iran) to detect endemic Leishmania species, namely leishmania major (L. major).Results:L. major was positive in PCR of Eight out of twenty-five examined samples.Conclusion:Cutaneous leishmaniasis may be misinterpreted as sarcoidosis; in endemic areas, when conventional methods fail to detect Leishmania parasite, PCR should be utilized in any granulomatous skin disease compatible with sarcoidosis, regardless of the clinical presentation or histopathological interpretation.

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Section: Discussionmentioning

confidence: 99%

Comorbidity of Leishmania major with cutaneous sarcoidosis

et al. 2014

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“…Tedavi bitiminde kontrol kemikiliği biyopsisinde amastigot görülmeyen olguda klinik ve laboratuar olarak yanıt alınmıştır (6). Literatürdeki benzer yayınlara baktığımızda VL gibi kutanöz ve mukokutanöz Leishmaniasis'in de malign hastalıkları taklit edebildiği dikkati çekmektedir (7)(8)(9). Di Cataldo ve ark.…”

Section: Discussionunclassified

Co-occurence of Visceral Leishmaniasis and Lymphoma

Erdem¹,

Taşbakan²,

Pullukçu³

et al. 2014

TurkiyeParazitolDerg

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ÖZETMalinite ve enfeksiyon klinik bulgu olarak birbirini taklit edebilen ve bu nedenle sıklıkla ayırıcı tanıda düşünülmesi gereken iki durumdur. Bu iki klinik durumun birlikteliği ise, immunsüpresif hastalar dışında oldukça nadirdir. Bu yazıda nedeni bilinmeyen ateş etiyolojisi araştırılırken önce Leishmaniasis tanısı alıp tedavi edilen ancak kontrol kemik iliği biyopsisinde diffuz B hücreli lenfoma olduğu saptanan bir hasta sunulmuştur. Ateş yüksekliği, kilo kaybı, karın ağrısı ve halsizlik yakınmaları ile başvuran ve malinite araştırılan hastanın, Bilgisayarlı Tomografi'sinde (BT) splenomegali ve biyokimyasal analizlerinde anemi ve hipergamaglobulinemi saptanmıştır. Leishmaniasis ön tanısı ile yapılan kemikiliği preparatında amastigotlar, NNN besiyerinde promastigot şekilleri görülmüştür. Liposomal Amfoterisin B tedavisi sonrasında uygulanan kontrol kemikiliği aspirasyonunda amastigot görülmeyen hastanın, patolojik bakısında diffüz büyük B hücreli lenfoma infiltrasyonu saptanmıştır. (Turkiye Parazitol Derg 2013; 37: 282-4 ABSTRACTClinicians have usually considered malignancies during follow up of patients who have infectious diseases as a pre-diagnosis. However, malignancy and an infectious disease are seen together more rarely, with the exception of immunosuppressed patients. This presentation is a case report followed up for fever of unknown origin. The patient was admitted to the hospital with the symptoms of fever, weight loss, abdominal pain and weakness. Anemia and hypergamaglobulinemia by biochemical analyses and splenomegaly by total body computed tomography were detected. Amastigotes were seen in bone marrow aspiration smears and promastigotes were isolated in NNN medium. At the end of the Liposomal Amphotericin B treatment, control bone marrow aspiration was applied. Leishmania amastigotes were not seen, while patient was diagnosed as diffuse B cell lymphoma pathologically. (Turkiye Parazitol Derg 2013; 37: 282-4)

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“…Başsorgun et al in their study of 28 patients from Turkey in 2015 evaluated the epidermal and dermal changes that would predict the histopathological diagnosis of cutaneous leishmaniasis and found that epidermal thinning/thickening, and orthokeratosis were early stage indicators, while exocytosis, hyperparakeratosis, and epidermal thinning were indicative of late stage disease [18]. Highly unlikely forms of presentation usually show a marked acanthosis or even wide areas of necrosis that can mimic other conditions such as squamous cell carcinoma, deep fungal infection or secondary syphilis, granulomatous lesions (sarcoidal and elastolytic) and simulating lupoid rosacea or granuloma annulare [19,20]. Non specific pathologies which can coexist with cutaneous leishmaniasis include inflammatory diseases (panniculitis, subacute spongiotic dermatitis, lichen planus) or infectious/granulomatous conditions (tuberculosis-like lesions, sarcoidosis, pityriasis lichenoides, indeterminate leprosy), and neoplastic lesions (mycosis, anaplastic T-cell lymphoma).…”

Section: Discussionmentioning

confidence: 99%