Unusual gestational choriocarcinoma arising in an interstitial pregnancy

Abstract

HighlightsChoriocarcinoma is a highly malignant trophoblastic neoplasm. Its association with ectopic pregnancy is very rare and aggressive.Clinical diagnosis of interstitial choriocarcinomas is difficult, since it is rare and manifested by non-specific symptoms.Imaging findings are also not helpful in ectopic location.Monitoring of βhCG level was the most useful marker of diagnosis and follow up.Pathology is the only tool of the diagnosis especially with the trend of treatment of ectopic pregnancy by conservative surgery.

Choriocarcinoma associated with ectopic pregnancy. A case report

“…The most common site of origin of Choriocarcinoma is uterus and occurs mainly a er the malignant transforma on of molar pregnancy, but some mes it has been seen a er term pregnancy, spontaneous abor on 1,2,4 or ectopic pregnancy at various sites. Choriocarcinoma 3,6 a er an ectopic pregnancy (0.76% to 4%) is a rare en ty. The reported incidence of ectopic tubal choriocarcinoma is approximately one in 5333 tubal pregnancies and 1.5/1,000,000 1,[3][4][5]7 births.…”

“…Choriocarcinoma 3,6 a er an ectopic pregnancy (0.76% to 4%) is a rare en ty. The reported incidence of ectopic tubal choriocarcinoma is approximately one in 5333 tubal pregnancies and 1.5/1,000,000 1,[3][4][5]7 births.…”

“…The occurrence of choriocarcinoma in very variable ranging 5 weeks to 15 years a er gesta on and can occur 1,3 even a er menopause. The incidence of choriocarcinoma a er ectopic gesta on is less but is very aggressive disease with around 30% presen ng with metastasis at me of diagnosis.…”

“…Though themolar pregnancy is the commonest cause for Choriocarcinoma, it can some mes occur following term pregnancy, spontaneous abor on, 1,2 and even a er ectopic pregnancy. Choriocarcinoma arising inectopic pregnancy is an extremely rare event with the 1,3 incidence of 1 in 5333 tubal pregnancies. Choriocarcinoma usually present with nonspecific symptoms and can mimic with different other clinical presenta ons like Hemorrhagic ovarian cyst, Tubo-ovarian abscess, Ovarian torsion, and ectopic pregnancy.…”

“…Different inves ga ons like USG and Serial measurement of β HCG level can help in early diagnosis and prompt ini a on of chemotherapy for the be er prognosis. Different treatment modali es including surgery and/or chemotherapy 3 depends upon the age, parity and severity of disease. Here we present a case who had undergone a laparoscopic salpingectomy for tubal ectopic pregnancy and was later diagnosed to have the Choriocarcinoma.…”