Unusual extra-podal fungal mycetoma with black grains in a Senegalese child

Seck, B.; Diop, Abdoulaye Ndoye; Ndiaye, M.; Diouf, Abdoulaye; Gueye, Fatou Diop; Fall, Fatou; Diallo, Mamadou Alpha; Ly, Fatimata

doi:10.1016/j.mycmed.2019.100914

Cited by 2 publications

(2 citation statements)

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“…Some dematiaceous fungi are also capable of forming a mycetoma, an infection of skin and subcutaneous tissue by fungi (eumycetoma) or filamentous bacteria (actinomycetoma) that is uniquely accompanied by swelling, draining tracts, and grains, which in eumycetomas contain abundant fungal hyphae. 8,9,13,16 These grains are a mix of fungal and host matrix components, including fungal polysaccharide cytoskeleton products. 13 Depending on the causative agent, grains can range from pale to black.…”

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confidence: 99%

Eumycetoma and disseminated phaeohyphomycosis in a Sumatran tiger

et al. 2021

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A 16-y-old female Sumatran tiger ( Panthera tigris sumatrae) was evaluated for hyporexia. Examination revealed chronic kidney disease and a large subcutaneous axillary mass with draining tracts that contained numerous small black grains. Histologic examination revealed the presence of intralesional fungal hyphae. Persistent hyporexia and pyogranulomatous disease, as well as progressive cachexia and azotemia occurred despite treatment, and euthanasia was performed. Disseminated phaeohyphomycosis was diagnosed on postmortem examination, additionally affecting various lymph nodes, the nasal cavity, mesenteric adipose tissue, abdominal aorta, pericardium, and kidney. Fungal culture from a deep-tissue sample isolated a pure growth of Curvularia sp., a dematiaceous opportunistic fungus able to cause eumycetomas and/or phaeohyphomycosis. Phaeohyphomycosis is a rare but emerging condition, not previously reported as disseminated disease in an exotic carnivore, to our knowledge. Aggressive systemic antifungal treatment was unsuccessful, likely complicated by diagnostic challenges and concurrent renal disease. The presence of a swelling with abundant grains exiting draining tracts should direct clinicians to the diagnosis of a mycetoma, warranting early and aggressive treatment.

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Eumycetoma and disseminated phaeohyphomycosis in a Sumatran tiger

et al. 2021

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“…Terbinafine use was also reported on a 13-year-old Senegalese boy with a dose of 750 mg per day. Nevertheless the boy passed away after 8 months of treatment [29]. The limited use of terbinafine could be attributed at least to its high cost and hepatotoxicity [30].…”

Section: Currently Used Drugs For Eumycetomamentioning

confidence: 99%