Unusual exophytic neurocytoma of thoracic spine mimicking meningioma: a case report and review of the literature

Tsai, Cheng-Yu; Tsai, Tai-Hsin; Lin, Chih-Hung; Lieu, Ann-Shung

doi:10.1007/s00586-010-1625-1

Cited by 16 publications

(20 citation statements)

References 14 publications

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“…It is important to differentiate this tumor from other CCTs, such as ependymomas, oligodendrogliomas, and central neurocytomas. 33 Clear cell meningiomas are often found in the cerebellopontine angle and the cauda equina. Although rare, meningiomas can occur in the ventricles, and if the morphology has clear cells, a diagnostic challenge arises in differentiating these tumors from central neurocytomas or clear cell ependymomas.…”

Section: Commentmentioning

confidence: 99%

Clear Cell Tumors of the Central Nervous System: A Case-Based Review

Camelo-Piragua

2012

Archives of Pathology &Amp; Laboratory Medicine

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Clear cell tumors of the central nervous system (CNS) encompass a variety of tumor subtypes that are challenging to diagnose given their similar morphologic features. Here, I use a case-based approach to review the clinicopathologic and radiologic features to help guide the general pathologist in the diagnosis of clear cell tumors of the CNS. First, the reader is invited to study 6 images of different CNS tumors with clear cell morphology. Then, each case is expanded in light of clinical and radiologic data and includes a histopathologic description of the tumor. A brief discussion follows with up-to-date diagnostic tools. Finally, I propose an immunohistochemical algorithm to navigate through the complex features that characterize clear cell tumors of the CNS. This review aims to provide a comprehensive approach to diagnosing clear cell neoplasms of the CNS based on improved assessment of the clinicopathologic and radiologic features of each entity.

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Section: Commentmentioning

confidence: 99%

Clear Cell Tumors of the Central Nervous System: A Case-Based Review

Camelo-Piragua

2012

Archives of Pathology &Amp; Laboratory Medicine

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“…CN is a low‐grade neoplasm that is characterized by its intraventricular localization, its occurrence predominantly in young adults, its histological resemblance to oligodendrogliomas, and its expression of neuronal markers . Shortly after the establishment of CN, similar tumors of the central nervous system were reported in several locations outside the supraventricular system as extraventricular neurocytomas (EVNs) . Histologically, EVN is an unusual tumor that is histologically composed of small uniform cells that demonstrate neuronal differentiation.…”

Section: Introductionmentioning

confidence: 99%

Malignant progression of an extraventricular neurocytoma arising from the VIIIth cranial nerve: A case report and literature review

et al. 2018

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A rare case of extraventricular neurocytoma (EVN) arising from the VIIIth cranial nerve in a 34‐year‐old woman is reported. The patient had a 20‐year history of hearing loss and facial palsy. Computed tomography showed a 3‐cm enhancing lesion in the left cerebellopontine angle (CPA). At operation, the tumor was seen to originate from the cochlear and vestibular nerves. The tumor was subtotally resected. Histologically, the tumor consisted of uniform cells with oval to round nuclei and scant cytoplasm. Immunohistochemically, the tumor cells were positive for synaptophysin, but negative for glial fibrillary acid protein and S‐100 protein. The Ki‐67 labeling index was 0%. Twelve years after the operation, magnetic resonance imaging (MRI) showed tumor recurrence at the left CPA. The tumor was subtotally resected, and radiation therapy was given. Histologically, the tumor consisted of round cells with mild atypia and one mitosis/20 high‐power fields (HPF). Immunohistochemically, tumor cells showed the same findings as the first operation sample, except for the Ki‐67 labeling index (3%). Twelve years after the second operation, MRI showed a second tumor recurrence at the left CPA and surroundings of the brain stem. The tumor was subtotally resected. Histologically, the tumor consisted of anaplastic short spindle cells and five mitoses/10 HPF. The immunohistochemical findings were almost the same as the earlier operation samples. However, the Ki‐67 labeling index was 20%. In addition, tumor cells from the third specimen were more strongly and more diffusely positive for GAB1 (growth factor receptor‐bound protein 2‐associated binding protein 1) compared to those of the earlier specimens. Electron microscopy showed the presence of numerous cell processes with a dense core and clear vesicles and microtubules. GAB1 immunostaining also indicated that malignant progression might be associated with the sonic hedgehog signaling pathways. To the best of our knowledge, this is the first report of an EVN arising from the VIIIth cranial nerve with malignant progression.

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“…But MRI is more sensitive in diagnosing tuberculous spondylitis. It can detect abnormal bone marrow with a low signal on T1-weighted images as well as a high signal on T2-weighted images which can not be detected by radiographs and CT scans [4,5]. In addition, special MRI sequences such as T1?…”

Section: Discussionmentioning

confidence: 99%

Isolated atypical spinal tuberculosis mistaken for neoplasia: case report and literature review

Wang

et al. 2012

Eur Spine J

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Introduction We report a case of isolated intra-spinal tuberculosis in a 45 year-old woman. The uncommon findings in MRI were more suggestive of tumor lesion. Materials and methods After 3 month history of low back pain and 2 weeks radiated pain of right lower extremity, an operation was performed and the total intra-spinal mass was resected. Histological examination revealed a granulomatous necrosis with caseum. Symptoms were greatly improved postoperatively and then the patient was treated with four anti-tuberculosis drugs. Conclusion This case indicated the complexity of differentiating atypical spinal tuberculosis from disease which could cause spinal cord and cauda equina compression.

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Unusual exophytic neurocytoma of thoracic spine mimicking meningioma: a case report and review of the literature

Cited by 16 publications

References 14 publications

Clear Cell Tumors of the Central Nervous System: A Case-Based Review

Clear Cell Tumors of the Central Nervous System: A Case-Based Review

Malignant progression of an extraventricular neurocytoma arising from the VIIIth cranial nerve: A case report and literature review

Isolated atypical spinal tuberculosis mistaken for neoplasia: case report and literature review

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