Unusual Effects of Metrizamide Lumbar Myelography

Kelley, Roger E.; Daroff, RB; Sheremata, W. A.; McCormick, Johnathon R.

doi:10.1001/archneur.1980.00500580084018

Cited by 22 publications

(2 citation statements)

References 19 publications

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“…A mild CSF pleocytosis often follows metrizamide studies, and occasional patients have symptomatic meningeal irritation characterized by nuchal rigidity and low-grade fever [43). One study described a patient in whom a severe meningeal reaction was followed by communicating hydrocephalus and Guillain-Barre syndrome [89]. Typical adhesive arachnoiditis similar to that following iophendylate and other myelographic agents has not been documented in humans as a consequence of metrizamide myelography, but it has been demonstrated in monkeys following the administration of large doses C6l).…”

mentioning

confidence: 99%

Neurotoxicity of radiological contrast agents

Junck

Marshall

1983

Annals of Neurology

209

137

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The most important complications of intravascular administration of contrast agents include idiosyncratic (anaphylactoid) reactions, shock, congestive heart failure, cardiac arrhythmias, acute renal failure, and neurotoxic effects. The incidence of serious neurotoxic effects is low. Entry of contrast agents into the central nervous system normally is limited but may be increased by osmotic opening of the blood-brain barrier with cerebral arteriography or arch aortography. Most neurotoxic effects are thought to represent direct effects of the contrast agent on brain or spinal cord. Adverse effects with arteriography include seizures, transient cortical blindness, brain edema, and spinal cord injury. Most cases of focal brain deficit (other than cortical blindness) are attributed to embolism secondary to the catheter. Seizures may occur with intravenous administration, especially in patients with brain tumors or other processes disrupting the blood-brain barrier. The most important adverse effects observed with myelographic agents include acute and chronic meningeal reactions with iophendylate, and seizures and transient encephalopathy with metrizamide.

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mentioning

confidence: 99%

Neurotoxicity of radiological contrast agents

Junck

Marshall

1983

Annals of Neurology

209

137

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“…Von einigen Autoren (104,163,205) wurde eine Korrelation zwischen der Tumorgröße und dem Ausmaß der Eiweißerhöhung gefunden. Die stärkere Eiweißerhöhung im Liquor bei größeren Tumoren hängt nach den yntersuchungen von Kasantikul et al (1980) von der ausgeprägteren Vaskularisierung der großen AN ab; das Endothel der Gefaße dieser Tumoren zeigt außerdem deutlich vom Normalen abweichende Strukturen und Verzahnungen (Long 1973 (1,11,62,64,67,86,91,114,130,145,194), so daß sie heute als obsolet angesehen werden müssen und nur noch in ausgesuchten Fällen zur Anwendung kommen sollten.…”

Section: Radiologische Diagnostikunclassified

Klinik und Diagnostik der Akustikusneurinome

Tackmann¹,

Bockenheimer²

1985

Fortschr Neurol Psychiatr

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The application of microsurgical techniques for the removal of acoustic neuromas has evidenced greatly improved postoperative results. Therefore the early detection of an acoustic neuroma is a special need for every neurologist. The development of new electrophysiological and radiological procedures now allows a far better approach in the diagnosis of acoustic neuromas. Brain stem auditory evoked potentials as well as acoustic reflex testing have shown to be rather sensitive tools in the diagnosis of retrocochlear pathology. Other electrophysiological procedures have been widely replaced by these techniques. Gasmeatocisternography in combination with cranial computed tomography is the method of choice in the detection of small acoustic neuromas. The current status in the application of different techniques for the diagnosis of acoustic neuromas is reviewed.

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