Unusual Cutaneous Cytomegalovirus Involvement in Patients With Acquired Immunodeficiency Syndrome

Bournérias, I

doi:10.1001/archderm.1989.01670210081012

Cited by 59 publications

(13 citation statements)

References 18 publications

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“…8 A wide spectrum of cutaneous manifestations of CMV infection has been reported in immunocompromised pediatric and adult patients, including transplant recipients and patients with acquired immune deficiency syndrome (AIDS). [9][10][11][12] Presentations of disseminated CMV disease from the literature include perianal and rectal ulceration, 13 indurated hyperpigmented nodules or plaques, 14 papular and pruritic eruptions, and vesiculobullous lesions. 15 CMV-associated ulcerative diaper dermatitis was reported in a 6-month-old AIDS patient.…”

Section: Discussionmentioning

confidence: 99%

Perineal ulcers in an infant: An unusual presentation of postnatal cytomegalovirus infection

Hancox¹,

Shetty

Sangüeza³

et al. 2006

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Perineal ulcers in an infant: An unusual presentation of postnatal cytomegalovirus infection

Hancox¹,

Shetty

Sangüeza³

et al. 2006

Journal of the American Academy of Dermatology

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“…Literature reports of skin lesions in immunocompromised patients vary from localized genital ulcerations to cutaneous ulceration of the chest [34], verrucous plaques of the heel [35], and crusted papules of the face [36]. Neonates with CMV may manifest petechiae, purpura, and jaundice [37••].…”

Section: Cytomegalovirusmentioning

confidence: 99%

Skin manifestations of herpesvirus infections

Toney

2005

Curr Infect Dis Rep

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Currently there are eight human herpesviruses identified that cause disease in both adults and children. Although the manifestations of disease differ with each herpesvirus, cutaneous presentations are common among almost all of them. These skin manifestations may be visually similar among several of these viruses, occasionally making it challenging to diagnose the patient's illness. Laboratory diagnostic testing is commercially available for most of these viruses. Because many herpesvirus infections are self-limiting in immunocompetent hosts, patients require only supportive care. Effective antiviral therapy is available for the more severe cases of infection caused by herpes simplex virus (HSV), varicella zoster virus (VZV), or cytomegalovirus (CMV). Healthcare practitioners should become familiar with the different cutaneous manifestations these viruses may exhibit.

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“… Those lesions due to postinfection immune derangement or hypersensitivity reactions arising from medical therapy, such as erythema nodosum or maculopapular rashes, respectively 6 Those lesions due to the presence of CMV in the endothelial cells of the dermal vessels, such as mucocutaneous ulcerations 4–7 or verrucous plaque 8 …”

mentioning

confidence: 99%

“…Those lesions due to the presence of CMV in the endothelial cells of the dermal vessels, such as mucocutaneous ulcerations 4–7 or verrucous plaque 8 …”

mentioning

confidence: 99%

Septal panniculitis associated with cytomegalovirus infection

Ballestero-Díez¹,

Álvarez-Ruiz²,

Montañés³

et al. 2005

Histopathology

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type VIN were strongly reactive to p16INK4 with a mean score of 5.5 (range 4-6, median ¼ 6), supporting their association with HPV ( Figure 1D).It is now generally accepted that there are at least two type of vulvar intraepithelial neoplasia (VIN): classic type VIN and simplex type VIN. Classic VIN is associated with HPV infection. 8 Currently, it is believed that simplex VIN is rarely associated with HPV infection. 4 In simplex VIN, p53 positive cells are often present above the basal cell layer whereas in classic VIN this does not occur. 4 Simplex VIN is also more frequently associated with well differentiated invasive squamous cell carcinoma.All of our classic VIN cases are strongly immunopositive with p16INK4 whereas 90% of our simplex VIN cases showed no reactivity to p16INK4 antibody. The remaining two cases exhibited focal weak positivity which may be considered negative in clinical practice, so that all of our classic VIN are positive and 100% of our simplex VIN are negative for p16INK4. Our study suggests that the immunohistochemical staining pattern of simplex VIN could thus be characterized as p16INK4 negative with p53 positive cells above the basal layer of the epidermis whereas classic warty type VIN is p16INK4 positive but negative for p53 in the supra-basilar layers.Our results affirm the current supposition that simplex VIN is usually a non-HPV-related lesion. Because of the higher rate of conventional invasive squamous cell carcinoma associated with simplex VIN, our findings support the premise that simplex VIN serves as a precursor to non-HPV-related invasive well differentiated squamous cell carcinoma of the vulva.

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Unusual Cutaneous Cytomegalovirus Involvement in Patients With Acquired Immunodeficiency Syndrome

Cited by 59 publications

References 18 publications

Perineal ulcers in an infant: An unusual presentation of postnatal cytomegalovirus infection

Perineal ulcers in an infant: An unusual presentation of postnatal cytomegalovirus infection

Skin manifestations of herpesvirus infections

Septal panniculitis associated with cytomegalovirus infection

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