Unusual constituents from the medicinal mushroomGanoderma lingzhi

Abstract

Extensive studies have revealed that triterpenoids, meroterpenoids, and polysaccharides are the main constituents of the well-known traditional Chinese medicinal mushroom Ganoderma.

Biological Activities of Secondary Metabolites from the Edible-Medicinal Macrofungi

“…Compounds 36, 37, 39, and 41 showed cytotoxicity against K562 cells, with IC 50 values of 68.2 ± 2.2, 45.3 ± 1.2, 33.1 ± 0.5, and 25.7 ± 1.7 µM, respectively (cisplatin as a positive drug, IC 50 = 3.8 ± 0.2 µM) [18]. Compound 47 showed obvious cytotoxic activity against HL-60, A-549, SMMC-7721, MCF-7, and SW480 cells, with the best suppressive activity on SW480 of the IC 50 value of 18.1 µM [19]. Compounds 48-52 showed cytotoxicity against MCF-7 at a concentration of 100 µM [20].…”

“…Morchella esculenta Morchellaceae 1-3 [13] Ganoderma lingzhi Ganodermataceae 4 [14] Macrolepiota procera Agaricaceae 5-16 [15] Fuscoporia torulosa Hymenochaetaceae 17-26 [16] Phellinus igniarius Polyporaceae 27-28 [17] Wolfiporia cocos Polyporaceae 29-46 [18] Ganoderma lingzhi Ganodermataceae 47 [19] Calvatia nipponica Lycoperdaceae 48-52 [20] Butyriboletus roseoflavus Boletaceae 53 [21] Ganoderma luteomarginatum Ganodermataceae 54-56 [22] Pleurotus florida Pleurotaceae 57 [23] Laetiporus sulphureus Polyporaceae 58-59 [24] Sarcosphaera crassa Pezizaceae 60-63 [25] Tricholoma ustaloides Tricholomataceae 64-65 [26] Lentinula edodes Omphalotaceae 66-68 [27] Ganoderma Ganodermataceae 69-72 [28] Ganoderma lucidum Ganodermataceae 73-75 [29] Morchella importuna Morchellaceae 76-78 [30] Oudemansiella raphanipes Tricholomataceae 79-81 [31] Sanghuangporus sanghuang Hymenochaetaceae 82-87 [32] Paxillus involutus Paxillaceae 88-93 [33] Paxillus involutus Paxillaceae 94-101 [34] Pleurotus ostreatus and Pleurotus eryngii Pleurotaceae 102-103 [35] Morehella importuna Morchellaceae 104-110 [36] Lepista sordida Tricholomataceae 111-112 [37] Poria cocos Wolf Polyporaceae 113-117 [38] Ganoderma lucidum Ganodermataceae 118 [39] Fomitopsis pinicola Coriolaceae 119-127 [40] Ganoderma orbiforme Ganodermataceae 128-129 [41] Inonotus obliquus Hymenochaetaceae 130-136 [42] Table 1. Cont.…”

Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015–2020)

“…An unusual type sesquiterpene 156 possessed an unusual 14(7-6)-cuparane scaffold (Scheme 5), and six rarely-encountered gymnomitrane-type sesquiterpenoids 157-162, were isolated from the medicinal mushroom Ganoderma lingzhi [75]. A new gymnomitrane-type sesquiterpenoid 163 was isolated from the fruiting body of Ganoderma lucidum [76].…”