Unusual Complication of Breast Implants: Brucella Infection

Memish, Ziad A.; Alazzawi, M.; Bannatyne, Robert M.

doi:10.1007/s15010-001-1129-3

Cited by 26 publications

(16 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three employees worked with isolates outside a BSC after misinterpretation of the Gram stain, all of whom developed LAB (27,35). Nine workers reportedly sniffed a culture plate of Brucella, five of whom developed LAB (AR, 56%) (13,14,28,(36)(37)(38). Exposure to Brucella sp.…”

Section: Resultsmentioning

confidence: 99%

“…Some workers experienced more severe signs, including soft tissue abscesses (some of which involved implants or prostheses) (35,37), spondylitis or sacroiliitis (26,33,35), and neurologic brucellosis (45). Chronic fatigue (34) and permanent hearing loss (46) were also reported.…”

Section: Resultsmentioning

confidence: 99%

“…Manipulation of unknown isolates in a BSC is considered unnecessary by some (65); however, this review suggests that it is a primary safety measure to prevent LAB, particularly for slow-growing Gramnegative or Gram-variable organisms. In addition, risky diagnos-tic methods, such as mouth pipetting and sniffing plates, should be prohibited due to the associated risk of infection (13,14,28,(36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

“…Air movement from a door causing airflow out of the BSC was identified in one outbreak (35,37), and unidentified lapses in safety were thought to have caused another (39). These reports, along with the cases reported to have never entered the laboratory (32,39), demonstrate the need for evaluation of ventilation systems, particularly following highly aerosolizing events.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A Literature Review of Laboratory-Acquired Brucellosis

et al. 2013

View full text Add to dashboard Cite

bBrucellosis is a bacterial zoonotic disease which has been associated with laboratory-acquired infections. No recent reviews have addressed the characteristics of laboratory-acquired brucellosis (LAB). English-language literature was reviewed to identify reports of laboratory exposures to Brucella spp. and LAB cases between 1982 and 2007. Evaluation of 28 case reports identified 167 potentially exposed laboratory workers, of whom 71 had LAB. Nine reports were identified that summarized an additional 186 cases of LAB. Only 18 (11%) exposures were due to laboratory accidents, 147 (88%) exposures were due to aerosolization of organisms during routine identification activities, and the circumstances of 2 (1%) exposures were unknown. Brucella melitensis was the causative agent in 80% (135/167) of the exposures. Workers with high-risk exposures were 9.3 times more likely to develop LAB than workers with low-risk exposures (95% confidence interval [CI], 3.0 to 38.6; P < 0.0001); they were also 0.009 times likelier to develop LAB if they took antimicrobial PEP than if they did not (95% CI, 0 to 0.042; P < 0.0001). The median incubation period in case and summary reports was 8 weeks (range 1 to 40 weeks). Antimicrobial PEP is effective in preventing LAB. The incubation period may be used to identify appropriate serological and symptom surveillance time frames for exposed laboratory workers.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Literature Review of Laboratory-Acquired Brucellosis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Three cases of human brucellosis have been reported associated with B. melitensis infection of breast implant patients. These involved patients who had either consumed unpasteurized cheese or sniffed B. melitensis cultures in a clinical laboratory (1,3,20,31).…”

mentioning

confidence: 99%

Novel Brucella Strain (BO1) Associated with a Prosthetic Breast Implant Infection

Stauffer

Koylass

et al. 2008

J Clin Microbiol

View full text Add to dashboard Cite

We report the microbiological, biochemical, and molecular characterization of an unusual Brucella strain (BO1) isolated from a breast implant wound in a 71-year-old woman with clinical symptoms consistent with brucellosis. Initial phenotypic analysis, including biochemical and antimicrobial susceptibility testing, cellular fatty acid analysis, and molecular analysis based on DNA-DNA reassociation and the presence of multiple copies of IS711 element suggested that the isolate was a Brucella-like organism, but species determination using microbiological algorithms was unsuccessful. Furthermore, molecular data based on 16S rRNA gene sequencing and multilocus sequence analysis demonstrated that BO1 was an unusual Brucella strain and not closely related to any currently described Brucella species. However, comparison with equivalent sequences in Ochrobactrum spp. confirms that the isolate is much more closely related to Brucella than to Ochrobactrum spp., and thus the isolate likely represents an atypical and novel strain within the genus Brucella.Brucellosis is primarily a zoonotic disease caused by members of the genus Brucella, which consists of six recognized species based on pathogenicity and host preferences: Brucella abortus (cattle), Brucella canis (dogs), Brucella melitensis (goats or sheep), Brucella suis (swine), Brucella ovis (rams), and Brucella neotomae (desert rats), as well as recently identified strains from marine mammals (5,10,13,26,34). Early studies on genomic DNA hybridization demonstrate a high degree of homology among the brucellae (40) and thus suggest the genus Brucella as one species, Brucella melitensis with several biovars (14), which has been confirmed by a number of molecular approaches, including 16S rRNA gene sequencing (21), multilocus enzyme electrophoresis (19), and whole-genome sequence analyses (15,24,36). However, because of the lack of widespread support the Brucella Taxonomy Subcommittee has recently returned to the traditional classification of the six Brucella nomenspecies with recognized biovars, along with two presumptive Brucella spp. from marine mammals: B. cetaceae and B. pinnipediae (34). Brucellae are intracellular facultative pathogens that infect many organs and soft tissues, including mammary glands, and frequently result in abortion, low milk production, and fetal death in animals (12,45).Most human disease is caused by B. abortus, B. suis, B. melitensis, and B. canis (13,22,35) and is most frequently associated with the consumption of unpasteurized dairy products or direct contact with infected animals or animal products (38,46). Brucellosis is also an occupational hazard of laboratory scientists infected by the inhalation of aerosols in a microbiology laboratory setting (32, 37). In humans, brucellosis is a systemic, febrile illness and can be associated with chronic debilitating infection of major organ systems that may include bone and the kidney, brain, epididymis, liver, ovary, and gallbladder (7,8,18,27). However, association of Brucella with infection of m...

show abstract

Successful Treatment of Acute Periprosthetic Breast Infection with Curettage, Pulse Lavage, and Immediate Device Exchange

Lorenzi¹

2005

Aesth Plast Surg

View full text Add to dashboard Cite

Unusual Complication of Breast Implants: Brucella Infection

Cited by 26 publications

References 14 publications

A Literature Review of Laboratory-Acquired Brucellosis

A Literature Review of Laboratory-Acquired Brucellosis

Novel Brucella Strain (BO1) Associated with a Prosthetic Breast Implant Infection

Successful Treatment of Acute Periprosthetic Breast Infection with Curettage, Pulse Lavage, and Immediate Device Exchange

Contact Info

Product

Resources

About