Unusual Complicated Gastric Ulcers

Bratucu, Mircea; Prunoiu, Virgiliu-Mihail; Strâmbu, Victor; Brătucu, E; Răvaş, Maria-Manuela; Simion, Laurentiu; Radu, Petru

doi:10.3390/medicina57121345

Cited by 5 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastric and duodenal ulcers were defined as mucosal defects with 5 mm or more diameter, and ulcers larger than 20 mm in diameter are considered giant ulcers [ 20 ]. In endoscopy, the size of the ulcers (5–10 mm, 11–20 mm, or more than 20 mm), the number of ulcers (single, double, or multiple), and the location of the ulcers (esophagus, gastric corpus including the fundus and body, antrum, angulus, and duodenum) were examined in both groups.…”

Section: Methodsmentioning

confidence: 99%

Peptic ulcer characteristics in oral opium and non-opium user patients with upper gastrointestinal bleeding

Masoodi,

Sabzikarian,

Masoodi

et al. 2024

BMC Gastroenterol

View full text Add to dashboard Cite

Background/Aims Upper gastrointestinal bleeding (UGIB) is a frequent medical issue. The primary risk factors for bleeding peptic ulcers are Helicobacter pylori infection and non-steroidal anti-inflammatory drugs. The association between acute gastric/duodenal ulcer and opium use has been previously proposed; however, there is no available data on endoscopic findings of patients with acute UGIB who use opium. Materials and methods In the present descriptive cross-sectional study, endoscopic data of 50 consecutive patients with oral opium use and 50 consecutive patients without any opium use who were admitted for UGIB were recorded. The size (5–10 mm, 11–20 mm, or more than 20 mm), number (single, double, or multiple), and location of the ulcers (esophagus, gastric corpus including the fundus and body, antrum, angulus, or duodenum) were examined by endoscopy in both groups. Results Three or more ulcers were observed in 46% and 16% of patients with oral opium use and without opium use, respectively (P-value = 0.001). The rate of giant ulcers (> 20 mm) was significantly higher in patients who used oral opium (40% vs. 12%; P-value = 0.007). Esophageal ulcers were also more common in oral opium users (30%) than non-users (8%) with UGIB (P-value = 0.01). Nevertheless, the location of the ulcers between the two groups generally was not statistically different. Conclusions This study has demonstrated that multiple, large peptic ulcers in GIB are potential complications of oral opium use. This could aid the needed modifications in the treatment protocol for these patients.

show abstract

Section: Methodsmentioning

confidence: 99%

Peptic ulcer characteristics in oral opium and non-opium user patients with upper gastrointestinal bleeding

Masoodi,

Sabzikarian,

Masoodi

et al. 2024

BMC Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Ethanol rapidly passes through the gastric mucosa, leading to membrane injury and endothelial damage in vessels, and a subsequent increase in mucosal permeability [ 107 ]. The vascular and microvascular changes are an early event in the development of gastric ulcer [ 108 ]. In rats, AST pretreatment (5 or 25 mg/kg BW; three days) significantly increased the activity of anti-oxidant enzymes such as SOD, CAT, and GPX in response to the ethanol-induced gastric ulcer [ 109 ].…”

Section: Gastric Ulcermentioning

confidence: 99%

Anti-Oxidant and Anti-Inflammatory Effects of Astaxanthin on Gastrointestinal Diseases

Lee

Kim

2022

IJMS

View full text Add to dashboard Cite

A moderate amount of reactive oxygen species (ROS) is produced under normal conditions, where they play an important role in cell signaling and are involved in many aspects of the immune response to pathogens. On the other hand, the excessive production of ROS destructs macromolecules, cell membranes, and DNA, and activates pro-inflammatory signaling pathways, which may lead to various pathologic conditions. Gastrointestinal (GI) mucosa is constantly exposed to ROS due to the presence of bacteria and other infectious pathogens in food, as well as alcohol consumption, smoking, and the use of non-steroidal anti-inflammatory drugs (NSAID). Prolonged excessive oxidative stress and inflammation are two major risk factors for GI disorders such as ulcers and cancers. Bioactive food compounds with potent anti-oxidant and anti-inflammatory activity have been tested in experimental GI disease models to evaluate their therapeutic potential. Astaxanthin (AST) is a fat-soluble xanthophyll carotenoid that is naturally present in algae, yeast, salmon, shrimp, and krill. It has been shown that AST exhibits protective effects against GI diseases via multiple mechanisms. Residing at the surface and inside of cell membranes, AST directly neutralizes ROS and lipid peroxyl radicals, enhances the activity of anti-oxidant enzymes, and suppresses pro-inflammatory transcription factors and cytokines. In addition, AST has been shown to inhibit cancer cell growth and metastasis via modulating cell proliferation-related pathways, apoptosis, and autophagy. Considering the potential benefits of AST in GI diseases, this review paper aims to summarize recent advances in AST research, focusing on its anti-oxidant and anti-inflammatory effects against gastric and intestinal ulcers and cancers.

show abstract

“…Gastric ulcer is a common disease occurring in different locations in the GI tract, such as the gastric angle, gastric antrum, and cardia 36 . Multiple gastric ulcers can occur at the same period 37 , and oral-taking drugs are widely used to treat ulcers. The therapeutic efficacy of oral-taking drugs is limited due to their low chemical stability in gastric fluid and shallow penetration in mucosa 38 .…”

Section: Introductionmentioning

confidence: 99%

A magnetic multi-layer soft robot for on-demand targeted adhesion

Chen,

Wang,

Chen

et al. 2024

Nat Commun

View full text Add to dashboard Cite

Magnetic soft robots have shown great potential for biomedical applications due to their high shape reconfigurability, motion agility, and multi-functionality in physiological environments. Magnetic soft robots with multi-layer structures can enhance the loading capacity and function complexity for targeted delivery. However, the interactions between soft entities have yet to be fully investigated, and thus the assembly of magnetic soft robots with on-demand motion modes from multiple film-like layers is still challenging. Herein, we model and tailor the magnetic interaction between soft film-like layers with distinct in-plane structures, and then realize multi-layer soft robots that are capable of performing agile motions and targeted adhesion. Each layer of the robot consists of a soft magnetic substrate and an adhesive film. The mechanical properties and adhesion performance of the adhesive films are systematically characterized. The robot is capable of performing two locomotion modes, i.e., translational motion and tumbling motion, and also the on-demand separation with one side layer adhered to tissues. Simulation results are presented, which have a good qualitative agreement with the experimental results. The feasibility of using the robot to perform multi-target adhesion in a stomach is validated in both ex-vivo and in-vivo experiments.

show abstract

Unusual Complicated Gastric Ulcers

Cited by 5 publications

References 26 publications

Peptic ulcer characteristics in oral opium and non-opium user patients with upper gastrointestinal bleeding

Peptic ulcer characteristics in oral opium and non-opium user patients with upper gastrointestinal bleeding

Anti-Oxidant and Anti-Inflammatory Effects of Astaxanthin on Gastrointestinal Diseases

A magnetic multi-layer soft robot for on-demand targeted adhesion

Contact Info

Product

Resources

About