Unusual clinical manifestations of dengue disease – Real or imagined?

Estofolete, Cássia Fernanda; Mota, Mânlio Tasso de Oliveira; Terzian, Ana Carolina Bernardes; Milhim, Bruno Henrique Gonçalves de Aguiar; Ribeiro, Milene Rocha; Nunes, Delzi Vinha; Mourão, Maria Paula Gomes; Rossi, Shannan L.; Nogueira, Maurício Lacerda; Vasilakis, Nikos

doi:10.1016/j.actatropica.2019.105134

Cited by 28 publications

(28 citation statements)

References 245 publications

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“…Our observations may not conclusively demonstrate that ILHV infection led to the brain hemorrhage and death in a patient with an acute neurological syndrome and underlying conditions (diabetes and hypertension). Considering the increasing incidence of arboviruses with unusual manifestations ( [51][52][53] and reviewed in [54][55][56]), and their potential tropism for the invasion of the CNS, leading to long-term neurofunctional sequelae, this report highlights the need for vigilance among physicians, healthcare providers, and researchers alike for arbovirus infections in patients presenting with meningoencephalitis and cerebrovascular events. Furthermore, this study demonstrates the importance of comprehensive arbovirus surveillance beyond urban arboviruses (e.g., DENV, CHIKV, and ZIKV), suggesting that urban and peri-urban populations may be at risk for ILHV infection and other emerging zoonotic arboviruses.…”

Section: Discussionmentioning

confidence: 98%

Fatal Outcome of Ilheus Virus in the Cerebrospinal Fluid of a Patient Diagnosed with Encephalitis

Milhim

Estofolete

Rocha

et al. 2020

Viruses

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Ilheus virus is an arbovirus with the potential for central nervous system involvement. Accurate diagnosis is a challenge due to similar clinical symptoms and serologic cross-reactivity with other flaviviruses. Here, we describe the first documented case of a fatal outcome following the identification of Ilheus virus in the cerebrospinal fluid (CSF) of a patient with cerebral encephalitis in Brazil.

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Section: Discussionmentioning

confidence: 98%

Fatal Outcome of Ilheus Virus in the Cerebrospinal Fluid of a Patient Diagnosed with Encephalitis

Milhim

Estofolete

Rocha

et al. 2020

Viruses

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“…Neurological events are uncommon, but an increase in these reports has occurred in recent years 7 . Sahu and colleges (2014) enrolled 486 patients and found an incidence rate of 9.26% of neurological complications in dengue fever patients 10 .…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of dengue involvement of the nervous system is not quite clear 4 . Such manifestations can result from the direct viral invasion of the nervous system due to its neurotropism, immune mediated mechanisms or vascular and metabolic abnormalities, as intracranial hemorrhage, cerebral edema, hyponatremia, hypokalemia, cerebral anoxia 7 .…”

Section: Bhushan Et Al (2018) Found 486% Of Immune-mediated Neurolomentioning

confidence: 99%

“…Dengue is a mosquito-borne viral disease caused by one of four dengue virus serotypes (DENV 1-4), that are genetically similar but antigenically distinct 4,5 . DENV is a small, spherical, lipid-enveloped viruses with a genome composed of a single-stranded, positivesense RNA virus of the genus Flavivirus, family Flaviviridae 6,7 . The disease is spread mainly by the female Mosquito Aedes aegypti, a vector that can be found in all tropical and subtropical regions, and by the Mosquito Aedes albopictus, in regions of temperate climate 5 .…”

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confidence: 99%

“…DF symptoms included acute fever, headaches, muscle ache, joint pain, gastroenteritis, and skin rashes 6 . Less than 5% of patients progress to severe life-threatening manifestations, usually seen in those who were previously exposed to heterotypic DENV infection 7 . In fact, the clinical outcome of dengue infection depends on several factors, both in the patient, in the vector, and in the virus itself 9 .…”

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confidence: 99%

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<strong>Dengue Fever and Neurology: Well Beyond Hemorrhage and Strokes</strong>

Schlindwein¹,

Bandeira²,

Breis³

et al. 2020

Preprint

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Dengue virus an arbovirus is endemic in an area that comprise almost half of the world's population, contrary to past beliefs that dengue virus differentiate from other neuroinvasive arbovirus due to its lack of neurological invasion and disease related neurological complications excluding hemorrhagic and thromboembolic , the body of evidence have grown to demonstrate a series of neurological manifestations linked to dengue virus with possible mechanisms involving direct virus invasion of the nervous system or immune mediated complications. In this review we provide a wide approach to this neglect but not so rare manifestations of a very common disease.

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The relationship between chikungunya virus and the kidneys: A scoping review

Costa

Gouveia

Silva

et al. 2022

Reviews in Medical Virology

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Several atypical forms of chikungunya fever (CHIK) have been described, including neurological, cardiac and renal involvement. These forms may be related to high morbidity and mortality rates. This scoping review based on the PubMed, Scopus, and WOS databases aims to identify and summarise all the available evidence regarding the clinical and histopathological presentations and risk factors associated with kidney injury related to CHIK, as well as the clinical impact. Thus, a total of 54 papers were selected from 1606 initial references after applying the defined inclusion criteria. Data on the association between kidney injury and CHIK are scarce, with studies only conducted in the acute phase of the disease, lacking further characterisation. Kidney injury incidence in hospitalised patients using the Kidney Disease Improving Global Outcomes criteria varies from 21% to 45%, being higher among patients with atypical and severe manifestations. Although acute kidney injury does not seem to be related to viraemia, it may be related to higher mortality.Few studies have described the renal histopathological changes in the acute phase of CHIK, with prevalent findings of acute interstitial nephritis with mononuclear infiltrate, glomerular congestion and nephrosclerosis. Only one study assessed the kidney function of patients in the subacute and chronic phases of CHIK. Additionally, individuals with comorbidities, including chronic kidney disease, may be among those with a greater risk of presenting worse outcomes when affected by CHIK. The results described herein may contribute to better understand the relationship between the kidneys and chikungunya virus.

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Unusual clinical manifestations of dengue disease – Real or imagined?

Cited by 28 publications

References 245 publications

Fatal Outcome of Ilheus Virus in the Cerebrospinal Fluid of a Patient Diagnosed with Encephalitis

Fatal Outcome of Ilheus Virus in the Cerebrospinal Fluid of a Patient Diagnosed with Encephalitis

<strong>Dengue Fever and Neurology: Well Beyond Hemorrhage and Strokes</strong>

The relationship between chikungunya virus and the kidneys: A scoping review

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