2007
DOI: 10.1590/s0004-27302007000800010
|View full text |Cite
|
Sign up to set email alerts
|

Unusual causes of Cushing's syndrome

Abstract: Although in the majority of the patients with Cushing's syndrome (CS), hypercortisolism is due to ACTH hypersecretion by a pituitary tumour or to ectopic ACTH secretion from an extrapituitary neoplastic lesion or to autonomous cortisol secretion by an adrenal tumour, in occasional patients a much rarer entity may be the cause of the syndrome. Herein, we attempted to summarise and categorise these unusual causes according to their presumed aetiology. To this end, we performed a comprehensive computer-based sear… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
16
0
3

Year Published

2010
2010
2019
2019

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 20 publications
(19 citation statements)
references
References 55 publications
0
16
0
3
Order By: Relevance
“…However, in the case presented here as well as that of seven other ectopic CRH cases, the lack of suppression of ACTH and cortisol are consistent ectopic ACTH production, avoiding the superfluous performance of other, sometimes invasive, pituitary-centered procedures (e.g. IPSS) [3]. Similarly, a single dose of 8 mg dexamethasone (overnight) has not suppressed cortisol in cases of isolated ectopic CRH [12,17].…”
Section: Discussionmentioning
confidence: 65%
See 1 more Smart Citation
“…However, in the case presented here as well as that of seven other ectopic CRH cases, the lack of suppression of ACTH and cortisol are consistent ectopic ACTH production, avoiding the superfluous performance of other, sometimes invasive, pituitary-centered procedures (e.g. IPSS) [3]. Similarly, a single dose of 8 mg dexamethasone (overnight) has not suppressed cortisol in cases of isolated ectopic CRH [12,17].…”
Section: Discussionmentioning
confidence: 65%
“…Although autonomous cortical adrenal adenomas or carcinomas are a cause of elevated cortisol, most cases (85 to 90%) are adrenocorticotropic hormone (ACTH) dependent and are caused by corticotroph pituitary adenomas (Cushing's Disease or CD) [1]. The remaining ACTH-dependent cases mostly involve non-pituitary malignancies (Ectopic ACTH) which often are tumors of neuroendocrine origin such as small cell lung carcinoma or bronchial carcinoid [3,4]. Here, we describe a case of Cushing's syndrome which initially appeared to be caused by ectopic ACTH secretion from metastatic small cell carcinoma.…”
Section: Introductionmentioning
confidence: 99%
“…Ectopic corticotroph adenomas located in the parasellar or cavernous sinuses behave similarly to anterior pituitary corticotroph adenomas during both stimulatory and suppression tests performed for the differential diagnosis of Cushing's disease . Moreover, inferior petrosal sinuses drain the whole cavernous sinus into the respective internal jugular veins, so IPSS results confirm the central origin of ACTH secretion.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, in patients with isolated ectopic CRH syndrome (ECS), baseline ACTH and cortisol levels are in the range usually found in patients with Boccult^ectopic ACTH syndrome or CD [1]. In those cases with ectopic secretion of both CRH and ACTH, the levels of ACTH and cortisol are variable.…”
Section: Discussionmentioning
confidence: 99%
“…Pituitary hyperfunction syndromes caused by ectopic hypersecretion of the corresponding hypothalamic hypophysiotropic hormones are extremely rare [1]. The most frequent cases are those of ectopic growth hormone releasing hormone production, causing GH hypersecretion [2].…”
Section: Introductionmentioning
confidence: 99%