Unusual cause of itching in a pregnancy (cholangiocarcinoma)

Sadoon, S.; Hodgett, Sheena

doi:10.1080/01443610801916296

Cited by 10 publications

(9 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of liver masses identified during pregnancy are more commonly benign [ 15 ], for example, hemangiomas, adenomas, hamartomas, and focal nodular hyperplasia [ 15 , 16 ]. Only a few cases of hepatocellular carcinoma were reported in the literature [ 15 ]; given the rarity of malignant liver lesions in pregnancy and that the presenting symptoms of malignancy may be confused with the common symptoms of pregnancy, the diagnosis is often delayed [ 5 , 15 ]. In addition, diagnostic and interventional modalities are limited in pregnancy, which might be another limiting factor in early diagnosis [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…CCA is extremely rare during pregnancy. We searched the PubMed database and found 9 cases in 8 reports of CCA in pregnancy from 1975 to 2015 [ 5 , 6 , 17 – 22 ]. We analyzed the 9 cases and the present case.…”

Section: Discussionmentioning

confidence: 99%

“…Other abnormal lab results were malignant hypercalcemia in one case and elevated bile acids in another [ 5 , 18 ]. The diagnosis mimicked obstetric cholestasis in one case [ 5 ], HELLP in another [ 6 ], and acute fatty liver of pregnancy in our case. The prognosis was generally poor: six of the women died shortly, up to 6 months, after diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…On average, CCAs have a 5-year survival rate of 5–10% [ 4 ]. CCA presents extremely rarely during pregnancy and can mimic other disorders, such as obstructive cholestasis or HELLP syndrome [ 5 , 6 ], which can lead to delayed diagnosis. We present a case of intrahepatic CCA that mimicked acute fatty liver of pregnancy (AFLP) and was subsequently diagnosed after delivery.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Intrahepatic Cholangiocarcinoma Masquerading as Acute Fatty Liver of Pregnancy: A Case Report and Review of the Literature

Qasrawi

Abughanimeh

Ghanimeh

et al. 2018

Case Reports in Hepatology

View full text Add to dashboard Cite

Cholangiocarcinoma (CCA) is an uncommon cancer and accounts only for 3% of all gastrointestinal malignancies. In this report, we present a case of an intrahepatic cholangiocarcinoma masquerading as acute fatty liver of pregnancy (AFLP). A 38-year-old female who is 36-week pregnant presented with a 1-week history of headache, nausea, vomiting, and right upper abdominal pain, along with hepatomegaly. Laboratory investigations were remarkable for mild leukocytosis, hyperbilirubinemia, proteinuria, and elevated transaminases and prothrombin time. Ultrasound of the liver revealed hepatomegaly, fatty infiltration, and a right hepatic lobe mass. Based on the overall picture, AFLP was suspected, and the patient underwent delivery by Cesarean section. However, bilirubin and liver enzyme levels gradually increased after delivery. MRI revealed a large dominant hepatic mass along with multiple satellite lesions in both lobes. Biopsy revealed the presence of intrahepatic CCA. CCA presenting during pregnancy is extremely rare with only 9 other cases reported in the literature. Therefore, the signs and symptoms can be easily confused with other more common disorders that occur during pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intrahepatic Cholangiocarcinoma Masquerading as Acute Fatty Liver of Pregnancy: A Case Report and Review of the Literature

Qasrawi

Abughanimeh

Ghanimeh

et al. 2018

Case Reports in Hepatology

View full text Add to dashboard Cite

show abstract

“…Biliary tract cancers during pregnancy have rarely been described in the literature. None of the five case reports available [22][23][24][25][26] mentions the application of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Administration of Gemcitabine for Metastatic Adenocarcinoma during Pregnancy: A Case Report and Review of the Literature

et al. 2014

View full text Add to dashboard Cite

We present the case of a 38-year-old woman diagnosed with metastatic adenocarcinoma of the biliary tract in the 18th week of pregnancy. Chemotherapy based on cisplatin and gemcitabine was administered, reaching disease stabilization until late-preterm delivery at 35 + 0 weeks of gestation. The infant was healthy and showed no malformations. Her head circumference was small, yet no neurological and behavioral defects have been detected. Development was normal during 14 months of follow-up. We discuss the implications of metastatic cancer in pregnancy with focus on therapeutic options for metastatic adenocarcinoma of the biliary tract. In this context, available data for the active regimens in biliary tract cancers—platinum compounds and gemcitabine—are discussed. This report is the fourth in the literature detailing the application of gemcitabine during pregnancy and the first presenting longer term follow-up, complementing available evidence that gemcitabine-based regimens are feasible in this situation.

show abstract

Mixed hepatocellular carcinoma and cholangiocarcinoma during pregnancy: a case report

Gerli

Favilli

Giordano

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

Unusual cause of itching in a pregnancy (cholangiocarcinoma)

Cited by 10 publications

References 6 publications

Intrahepatic Cholangiocarcinoma Masquerading as Acute Fatty Liver of Pregnancy: A Case Report and Review of the Literature

Intrahepatic Cholangiocarcinoma Masquerading as Acute Fatty Liver of Pregnancy: A Case Report and Review of the Literature

Administration of Gemcitabine for Metastatic Adenocarcinoma during Pregnancy: A Case Report and Review of the Literature

Mixed hepatocellular carcinoma and cholangiocarcinoma during pregnancy: a case report

Contact Info

Product

Resources

About