Unusual case of primary pulmonary Hodgkin’s lymphoma presenting with a continuous murmur

Luca, Conti; Pisani, David; Gatt, Alfred; Montefort, Stephen

doi:10.1136/bcr-2018-225674

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…A database search identified 101 cases between 1990 and 2020 (Table 1 ). 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 Most cases were diagnosed by surgical biopsy (85 cases), followed by CT‐guided biopsy (eight cases) and TBB (four cases).…”

Section: Case Reportmentioning

confidence: 99%

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Diagnostic utility of transbronchial biopsy for Hodgkin's lymphoma: A case study

et al. 2021

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Lung lesions of Hodgkin's lymphoma (HL) are rare and difficult to diagnose by nonsurgical biopsy. We herein present the case of a 72-year-old Japanese male who presented with accumulation of lung infiltrates and masses bilaterally on the lungs for 3 years. Although transbronchial lung biopsy (TBB) and computed tomographyguided biopsy were conducted several times, his diagnosis remained inconclusive. On further deterioration of lung lesions, the patient was transferred to our hospital. Positron emission tomography revealed increased accumulation in the bilateral lungs and right supraclavicular lymph nodes. Surgical biopsy of the lymph node was performed. He was finally diagnosed with HL and underwent chemotherapy with doxorubicin, vinblastine, dacarbazine, and brentuximab vedotin. After chemotherapy, the lung lesion showed significant regression. A literature review indicated that the diagnostic success rate of TBB was low (18.5%) in cases of lung lesions in HL.

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Section: Case Reportmentioning

confidence: 99%

“…A database search identified 101 cases between 1990 and 2020 (Table 1). 1–25 Most cases were diagnosed by surgical biopsy (85 cases), followed by CT‐guided biopsy (eight cases) and TBB (four cases).…”

Section: Case Reportmentioning

confidence: 99%

Diagnostic utility of transbronchial biopsy for Hodgkin's lymphoma: A case study

et al. 2021

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Clinicopathological Characteristics of Primary Pulmonary Hodgkin Lymphoma (PPHL): Two Institutional Experiences with Comprehensive Literature Review of 115 PPHL Cases

Jung

Kim

Han

et al. 2022

JCM

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Primary pulmonary Hodgkin lymphoma (PPHL) is an extremely rare condition. Its clinicopathological characteristics remain unclear because of the limited number of patients with PPHL. The aim of this study was to comprehensively analyze the clinicopathological characteristics of PPHL. We reviewed the electronic medical records and pathology slides of our 10 PPHL patients. The female-to-male ratio was 6:4, and the mean age was 41 years. Although three patients had no symptoms, seven had localized or generalized symptoms, including cough, sputum, chest discomfort/pain, and weight loss. Some cases had not been diagnosed as PPHL in the initial needle biopsy. Four patients underwent surgical resection. With chemotherapy, eight patients achieved complete remission. We also conducted a thorough literature review on 105 previously reported PPHL cases. Among a total of 115 PPHL cases, the most common subtype was nodular sclerosis (37.4%). More than half of the cases (55%) were clinically suspected as infectious pneumonia. Of 61 patients whose biopsies were available, 27 (44.3%) were diagnosed correctly as Hodgkin lymphoma, whereas the misdiagnoses included tuberculosis, Langerhans cell histiocytosis, solitary fibrous tumor, and adenocarcinoma. We demonstrated that PPHL represents a diagnostic challenge on small biopsies. Recognizing that this rare tumor can mimic infectious and inflammatory diseases as well as malignancies is important because the accurate diagnosis of PPHL is essential for adequate clinical management.

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Unusual case of primary pulmonary Hodgkin’s lymphoma presenting with a continuous murmur

Cited by 2 publications

References 20 publications

Diagnostic utility of transbronchial biopsy for Hodgkin's lymphoma: A case study

Diagnostic utility of transbronchial biopsy for Hodgkin's lymphoma: A case study

Clinicopathological Characteristics of Primary Pulmonary Hodgkin Lymphoma (PPHL): Two Institutional Experiences with Comprehensive Literature Review of 115 PPHL Cases

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