Unusual Case of Disseminated Amyloidosis in a Man in His 30s Presenting as Coagulopathy, Recurrent Pancreatitis, and Acute Kidney Injury

Abstract

Amyloidosis is a collective term for a debilitating and progressive disease characterized by the extracellular deposition of abnormal proteins. These abnormal proteins can either be deposited in a localized place, such as a single organ, or, as is the case with our patient, deposited throughout the entire body.Unlike our patient, who was in his early 30s, the average age of patients diagnosed with AL amyloidosis is 65 years, and <10% of patients are younger than 50 years. 1 Although bleeding disorders are associated with AL amyloidosis, our patient had coagulopathy caused by amyloidosis-induced acquired factor X deficiency, which is remarkably rare. In addition, our patient previously had idiopathic pancreatitis diagnosed, which was also eventually attributed to significant amyloidosis affecting the organ, based on autopsy