Unusual Case of an Infant with Urinary Tract Infection Presenting as Cholestatic Jaundice

Niazi, Rahaf; Baharoon, Bashaer Saleh; Neyas, Afnan; Alaifan, Meshari A.; Safdar, Osama Y

doi:10.1155/2018/9074245

Cited by 2 publications

(3 citation statements)

References 17 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All bacteria actually identified in urosepsis causing jaundice are able to secrete hemolysin, a toxic protein which causes erythrocyte destruction and the release of their hemoglobin content into the blood stream. 13 Hemoglobin in blood stream is then successively transformed into biliverdin and indirect bilirubin through the actions of the enzymes heme oxygenase and biliverdin reductase respectively.…”

Section: Discussion Of Pathophysiologymentioning

confidence: 99%

The pathophysiology of neonatal jaundice in urosepsis is complex with mixed bilirubin!!!

Moyo¹,

Um²,

Awa³

et al. 2022

JPNC

View full text Add to dashboard Cite

Urinary tract infection is one of the most common type of infections in neonates, with the capacity to induce neonatal jaundice which is another major emergency in neonates. However, the pathophysiology of this comorbidity is still poorly described in neonatology and the clinical implications insufficiently illustrated. The aim of this review is to contribute to shed more light over this issue in order to improve understanding and orientate therapeutic interventions. In this piece of work, we did a critical study of recent and pertinent articles on the topic available online. This enabled us to make a synthesis of current classifications of neonatal jaundice, with epidemiological, etiological and pathophysiological aspects of the comorbidity with urosepsis being discussed. We conclude with consequent therapeutic implications.

show abstract

Section: Discussion Of Pathophysiologymentioning

confidence: 99%

The pathophysiology of neonatal jaundice in urosepsis is complex with mixed bilirubin!!!

Moyo¹,

Um²,

Awa³

et al. 2022

JPNC

View full text Add to dashboard Cite

show abstract

“…Kolestasis akibat infeksi karena endotoksin bakteri (terutama gram negatif ) menyebabkan disfungsi pengambilan dan ekskresi bilirubin, serta terjadi inhibisi aktivitas transporter dan ekspresi gen yang berfungsi transpor asam empedu oleh lipopolisakarida. [12][13][14] Tatalaksana dukungan nutrisi bertujuan untuk mendukung pertumbuhan optimal, karena pada kolestasis neonatal sering terjadi gagal tumbuh akibat malabsorpsi lemak, gangguan metabolisme protein dan karbohidrat, serta peningkatan kebutuhan metabolik. 2 Jumlah kalori diberikan 120-150% kebutuhan bayi normal.…”

Section: Laporan Kasusunclassified

“…2 Terapi suportif lain adalah stimulasi aliran empedu menggunakan asam ursodeoksikolat (10-20 mg/kgBB/hari). 6,13 Selain stimulasi aliran empedu, obat ini berfungsi hepatoprotektor dan membantu absorpsi lemak. 6 Obat lain yaitu kolestiramin (0,25-0,5 g/kgBB/hari), atau rifampisin (5-10 mg/kgBB/hari).…”

Section: Laporan Kasusunclassified

Kolestasis Neonatal di Rumah Sakit Umum Daerah Wangaya, Bali

Isella

Dewi

2021

CDK

View full text Add to dashboard Cite

Kolestasis neonatal terjadi akibat kelainan sistem hepatobiliar, sering terlambat didiagnosis karena dianggap fisiologis. Identifikasi dini, menentukan etiologi hingga merujuk ke bagian gastroenterologi-hepatologi anak pada saat yang tepat adalah penting untuk keberhasilan terapi dan prognosis yang optimal. Kasus seorang bayi laki-laki usia 3 minggu dengan keluhan muntah, diare, tubuh kuning, dan tinja kuning pucat. Pada pemeriksaan laboratorium didapatkan hiperbilirubinemia disertai peningkatan kadar bilirubin direk, gama glutamil transferase (GGT), peningkatan hitung leukosit dan trombosit; pemeriksaan tinja menunjukkan infeksi bakteri. Diagnosis kolestasis berdasarkan peningkatan bilirubin direk >20% kadar bilirubin total, mengarah pada tipe intrahepatal berdasarkan peningkatan GGT <10 kali lipat batas atas normal. Pasien mendapat terapi antibiotik, disertai terapi suportif stimulasi aliran empedu dan vitamin larut lemak.Neonatal cholestasis is caused by the abnormality of the hepatobiliary system, often unrecognized and late-diagnosed because of misinterpretation as physiological jaundice. Early identification of the underlying etiology and timely referral to pediatric gastroenterology and epatology are important for successful treatment and optimal prognosis. We reported a male infant age 3 weeks with vomiting, diarrhea, icterus, and pale stool. Laboratory findings were hyperbilirubinemia with high direct bilirubin, gamma-glutamyl-transferase (GGT), elevated leukocyte and thrombocytes, and stool test indicated bacterial infection. Diagnosis of cholestasis is based on high direct bilirubin >20% total bilirubin, with intrahepatic type based on elevated GGT <10 times from the upper limit. The patient was treated with antibiotics and supportive treatment of bile flow stimulant and fat-soluble vitamin

show abstract

Unusual Case of an Infant with Urinary Tract Infection Presenting as Cholestatic Jaundice

Cited by 2 publications

References 17 publications

The pathophysiology of neonatal jaundice in urosepsis is complex with mixed bilirubin!!!

The pathophysiology of neonatal jaundice in urosepsis is complex with mixed bilirubin!!!

Kolestasis Neonatal di Rumah Sakit Umum Daerah Wangaya, Bali

Contact Info

Product

Resources

About